Next Article in Journal
Efficiency of Emission Control Measures on Particulate Matter-Related Health Impacts and Economic Cost during the 2014 Asia-Pacific Economic Cooperation Meeting in Beijing
Previous Article in Journal
Changes in Depressive Symptoms among Older Adults with Multiple Chronic Conditions: Role of Positive and Negative Social Support
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2017, 14(1), 18; doi:10.3390/ijerph14010018

Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome

1
Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai 200092, China
2
Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong 250100, China
3
Ministry of Education-The Key Laboratory of Reproductive Endocrinology, Shandong University, Shandong 250100, China
4
Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China
5
Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200092, China
*
Author to whom correspondence should be addressed.
Academic Editor: Huixiao Hong
Received: 24 November 2016 / Revised: 20 December 2016 / Accepted: 22 December 2016 / Published: 27 December 2016
(This article belongs to the Section Environmental Health)
View Full-Text   |   Download PDF [538 KB, uploaded 27 December 2016]   |  

Abstract

To better understand possible effects of bisphenol A (BPA) exposure on ovarian reserve in women with polycystic ovary syndrome (PCOS), we measured creatinine adjusted urinary BPA (BPA_Cre) concentrations and used regression models to evaluate the association between urinary BPA level and antral follicle count (AFC), antimullerian hormone (AMH), day-3 follicle stimulating hormone levels (FSH) and inhibin B (INHB) in 268 infertile women diagnosed with PCOS. BPA was detected in all women with a median concentration of 2.35 ng/mL (the 25th and 75th percentiles of 1.47 ng/mL and 3.95 ng/mL). A unit increase in BPA_Cre was associated with a significant decrease of 0.34 in AFC (β = −0.34, 95% CI = −0.60, −0.08; p = 0.01). Likewise, BPA was negatively associated with AMH and day-3 FSH levels, but neither of them reached statistical significance. No association was observed between BPA and INHB. Our results suggest that in women with PCOS, BPA may affect ovarian follicles and, therefore, reduce ovarian reserve. View Full-Text
Keywords: bisphenol A; ovarian reserve; antral follicle count; antimullerian hormone; day-3 follicle stimulating hormone bisphenol A; ovarian reserve; antral follicle count; antimullerian hormone; day-3 follicle stimulating hormone
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhou, W.; Fang, F.; Zhu, W.; Chen, Z.-J.; Du, Y.; Zhang, J. Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome. Int. J. Environ. Res. Public Health 2017, 14, 18.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top