Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Literature Search
2.2. Eligibility Criteria
2.3. Exclusion Criteria
2.4. Data Extraction
2.5. Quality Assessment for Individual Studies
2.6. Data Analysis
3. Results
3.1. Selection and Characteristics of Studies
3.2. Association between the CETP TaqIB Polymorphism and the Composite Ischemic CVD Risk
3.3. Association between the CETP TaqIB Polymorphism and HDL-C Concentrations
3.4. Sensitivity Analysis
3.5. Heterogeneity Analysis
3.6. Publication Bias
4. Discussion
5. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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First Author | Year | Country | Ethnicity | Disease | Source of Controls | Study Type | Size (Case/Control) | MAF | HWE | Genotypes Distribution (Case/Control) | Score | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
B1B1 | B1B2 | B2B2 | |||||||||||
Tenkanen et al. [51] | 1991 | Finland | Caucasian | MI | PB | CS | 72/115 | 0.44 | Yes | 19/33 | 40/65 | 13/17 | 8 |
Fumeron et al. [41] | 1995 | France | Caucasian | MI | PB | CCS | 608/724 | 0.40 | Yes | 209/258 | 312/346 | 87/120 | 8 |
Kuivenhoven et al. [44] | 1998 | The Netherlands | Caucasian | CAD | PB | CS | 380/427 | 0.41 | Yes | 129/152 | 183/214 | 68/61 | 7 |
Wu et al. [33] | 2001 | China | Asian | MI | HB | CCS | 149/274 | 0.46 | Yes | 45/63 | 79/159 | 25/52 | 8 |
Arca et al. [38] | 2001 | Italy | Caucasian | CAD | PB | CCS | 408/180 | 0.41 | Yes | 153/67 | 187/77 | 68/36 | 8 |
Eiriksdottir et al. [40] | 2001 | Iceland | Caucasian | MI | PB | CS | 378/745 | 0.45 | No | 128/194 | 191/396 | 59/155 | 8 |
Liu et al. [45] | 2002 | USA | Caucasian | MI | PB | CS | 384/384 | 0.43 | Yes | 125/122 | 196/193 | 63/69 | 8 |
Freeman et al. [56] | 2003 | UK | Caucasian | MI | PB | CS | 499/1105 | 0.50 | Yes | 164/239 | 259/541 | 76/225 | 8 |
Zhang et al. [35] | 2003 | China | Asian | CAD | HB | CCS | 234/164 | 0.41 | No | 76/49 | 126/95 | 32/20 | 6 |
Qin et al. [29] | 2004 | China | Asian | CAD | HB | CCS | 249/167 | 0.41 | Yes | 81/49 | 131/97 | 37/21 | 6 |
Wang et al. [32] | 2004 | China | Asian | CAD | HB | CCS | 128/247 | 0.42 | Yes | 50/72 | 66/123 | 12/52 | 6 |
Yan et al. [34] | 2004 | China | Asian | CAD | HB | CCS | 106/64 | 0.41 | Yes | 41/19 | 46/34 | 19/11 | 6 |
Zhao et al. [36] | 2004 | China | Asian | CAD | HB | CCS | 238/203 | 0.41 | No | 95/60 | 105/109 | 38/34 | 6 |
Zheng et al. [37] | 2004 | China | Asian | CAD | HB | CCS | 203/100 | 0.39 | Yes | 66/33 | 114/55 | 23/12 | 6 |
Bernard et al. [43] | 2004 | UK | Caucasian | MI | PB | CCS | 4442/3273 | 0.43 | No | 1477/1100 | 2175/1527 | 790/646 | 8 |
Yilmaz et al. [42] | 2005 | Turkey | Caucasian | MI | PB | CCS | 173/111 | 0.42 | No | 66/39 | 72/46 | 35/26 | 6 |
Fidani et al. [63] | 2005 | Greek | Caucasian | IS | HB | CCS | 96/100 | 0.41 | Yes | 35/34 | 47/45 | 14/21 | 6 |
Whiting et al. [53] | 2005 | USA | Caucasian | CAD | PB | CS | 2392/827 | 0.42 | Yes | 792/279 | 1200/377 | 400/171 | 8 |
Zhang et al. [54] | 2005 | China | Asian | CAD | PB | CCS | 88/94 | 0.41 | Yes | 31/32 | 40/50 | 17/12 | 6 |
Dedoussis et al. [57] | 2007 | Greece | Caucasian | MI | HB | CCS | 237/237 | 0.41 | Yes | 83/78 | 121/120 | 33/39 | 7 |
Morgan et al. [58] | 2007 | USA | Caucasian | MI | HB | CCS | 805/656 | 0.44 | No | 250/224 | 387/297 | 168/135 | 6 |
Hsieh et al. [59] | 2007 | China | Asian | CAD | HB | CCS | 101/264 | 0.31 | Yes | 19/23 | 47/111 | 35/130 | 5 |
Quarta et al. [64] | 2007 | Italy | Caucasian | IS | HB | CCS | 215/236 | 0.43 | Yes | 79/73 | 105/108 | 31/55 | 6 |
Muendlein et al. [27] | 2008 | Austria | Caucasian | CAD | HB | CS | 332/225 | 0.40 | Yes | 125/71 | 162/116 | 45/38 | 8 |
Rejeb et al. [30] | 2008 | Tunisian | Caucasian | CAD | HB | CS | 212/104 | 0.41 | Yes | 104/45 | 93/47 | 15/12 | 8 |
Meiner et al. [48] | 2008 | USA | Caucasian | MI | PB | CCS | 550/620 | 0.45 | Yes | 173/166 | 282/320 | 95/134 | 6 |
Wang et al. [52] | 2008 | China | Asian | CAD | PB | CCS | 317/298 | 0.41 | Yes | 117/99 | 148/146 | 52/53 | 6 |
Jensen et al. [62] a | 2008 | USA | Caucasian | MI | PB | CS | 247/486 | 0.42 | Yes | 84/166 | 120/235 | 42/85 | 8 |
Jensen et al. [62] b | 2008 | USA | Caucasian | MI | PB | CS | 259/513 | 0.41 | Yes | 89/180 | 126/244 | 44/89 | 8 |
Padmaja et al. [28] | 2009 | Indian | Asian | CAD | HB | CCS | 504/338 | 0.45 | Yes | 163/86 | 264/161 | 77/91 | 6 |
Poduri et al. [49] | 2009 | India | Asian | MI | PB | CCS | 265/150 | 0.41 | Yes | 117/3 | 107/82 | 41/35 | 6 |
Tanrikulu-Kucuk et al. [23] | 2010 | Turkey | Caucasian | CAD | HB | CCS | 135/112 | 0.46 | No | 40/33 | 71/50 | 24/29 | 6 |
Corella et al. [39] | 2010 | Spanish | Caucasian | CAD | PB | CS | 557/1180 | 0.47 | Yes | 224/482 | 247/537 | 86/161 | 8 |
Bhanushali et al. [66] | 2010 | Indian | Asian | CAD | HB | CCS | 90/150 | 0.46 | Yes | 33/38 | 40/77 | 17/35 | 7 |
Kolovou et al. [25] | 2011 | Greek | Caucasian | CAD | HB | CCS | 374/96 | 0.42 | Yes | 126/22 | 202/45 | 46/29 | 6 |
Zhang et al. [55] | 2011 | China | Asian | CAD | PB | CCS | 334/301 | 0.34 | Yes | 172/136 | 106/120 | 56/45 | 8 |
Jiang et al. [65] | 2012 | China | Asian | IS | HB | CCS | 220/220 | 0.29 | Yes | 130/103 | 72/86 | 18/31 | 6 |
Tayebi et al. [61] | 2012 | Singapore | Asian | CAD | HB | CCS | 659/927 | 0.45 | Yes | 228/245 | 322/491 | 109/191 | 7 |
Lu et al. [46] | 2013 | Singapore | Asian | CAD | PB | CCS | 659/927 | 0.45 | Yes | 228/245 | 322/491 | 109/191 | 8 |
Mehlig et al. [47] | 2014 | Sweden | Caucasian | CAD | PB | CCS | 618/2921 | 0.43 | Yes | 209/938 | 313/1420 | 96/563 | 8 |
El-Aziz et al. [50] | 2014 | Egypt | Caucasian | CAD | PB | CCS | 116/119 | 0.46 | Yes | 38/30 | 60/57 | 18/32 | 6 |
Kaman et al. [24] | 2015 | Turkey | Caucasian | CAD | HB | CCS | 210/100 | 0.44 | Yes | 44/29 | 81/45 | 85/26 | 6 |
Liu et al. [26] | 2015 | China | Asian | CAD | HB | CCS | 322/108 | 0.42 | Yes | 113/40 | 145/47 | 64/21 | 6 |
Shi et al. [31] | 2015 | China | Asian | CAD | HB | CCS | 312/88 | 0.42 | Yes | 112/29 | 138/44 | 62/15 | 6 |
Cyrus et al. [60] | 2016 | Saudi Arabia | Caucasian | CAD | PB | CCS | 990/618 | 0.41 | Yes | 376/183 | 454/321 | 160/114 | 6 |
First Author | Year | Country | Ethnicity | MAF | HWE | B1B1 | B1B2 | B2B2 | Score | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | n | Mean | SD | n | Mean | SD | n | |||||||
Kuivenhoven et al. [44] | 1998 | The Netherlands | Caucasian | 0.41 | Yes | 0.88 | 0.21 | 281 | 0.93 | 0.21 | 397 | 1.01 | 0.26 | 129 | 7 |
Gudnason et al. [67] | 1999 | Mixed | Caucasian | 0.44 | Yes | 1.13 | 0.21 | 237 | 1.19 | 0.24 | 380 | 1.27 | 0.22 | 150 | 7 |
Eiriksdottir et al. [40] | 2001 | Iceland | Caucasian | 0.45 | Yes | 1.09 | 0.31 | 328 | 1.12 | 0.29 | 596 | 1.25 | 0.40 | 210 | 8 |
Goto et al. [68] | 2001 | Japan | Asian | 0.43 | Yes | 1.14 | 0.28 | 37 | 1.23 | 0.37 | 47 | 1.23 | 0.33 | 22 | 6 |
Talmud et al. [8] | 2002 | UK | Caucasian | 0.45 | Yes | 0.79 | 0.25 | 500 | 0.84 | 0.25 | 896 | 0.90 | 0.27 | 317 | 6 |
Liu et al. [45] | 2002 | USA | Caucasian | 0.43 | Yes | 1.17 | 0.28 | 247 | 1.24 | 0.34 | 389 | 1.30 | 0.34 | 132 | 8 |
Goff et al. [69] | 2002 | UK and France | Caucasian | 0.47 | Yes | 1.33 | 0.40 | 410 | 1.29 | 0.60 | 889 | 1.26 | 0.45 | 504 | 7 |
Zhang et al. [35] | 2003 | China | Asian | 0.41 | No | 1.26 | 0.22 | 125 | 1.30 | 0.25 | 221 | 1.42 | 0.22 | 52 | 6 |
Katsunori et al. [70] | 2003 | Japan | Asian | 0.4 | Yes | 1.32 | 0.46 | 217 | 1.43 | 0.57 | 279 | 1.59 | 0.62 | 95 | 7 |
Zhao et al. [36] | 2004 | China | Asian | 0.41 | Yes | 1.19 | 0.36 | 155 | 1.27 | 0.34 | 214 | 1.38 | 0.39 | 72 | 6 |
Weitgasser et al. [71] | 2004 | Austrian | Caucasian | 0.41 | Yes | 1.49 | 0.39 | 358 | 1.55 | 0.41 | 475 | 1.67 | 0.41 | 184 | 7 |
Jiang et al. [72] | 2005 | China | Asian | 0.37 | No | 1.16 | 0.27 | 49 | 1.20 | 0.33 | 38 | 1.34 | 0.29 | 21 | 6 |
Whiting et al. [53] | 2005 | USA | Caucasian | 0.42 | Yes | 0.91 | 0.33 | 1071 | 0.95 | 0.34 | 1577 | 1.00 | 0.38 | 571 | 8 |
Huang et al. [73] | 2006 | China | Asian | 0.40 | Yes | 1.08 | 0.29 | 121 | 1.13 | 0.29 | 163 | 1.27 | 0.48 | 56 | 6 |
Zhang et al. [74] | 2007 | China | Asian | 0.40 | No | 1.26 | 0.31 | 24 | 1.34 | 0.35 | 20 | 1.42 | 0.43 | 13 | 6 |
Cui et al. [75] | 2007 | China | Asian | 0.46 | Yes | 1.44 | 0.32 | 17 | 1.58 | 0.46 | 24 | 1.54 | 0.36 | 13 | 6 |
Meena et al. [76] | 2007 | Indian | Asian | 0.21 | No | 1.20 | 0.20 | 15 | 1.10 | 0.10 | 36 | 1.10 | 0.20 | 106 | 6 |
Hsieh et al. [59] | 2007 | China | Asian | 0.31 | Yes | 43.31 | 10.63 | 42 | 43.39 | 11.09 | 158 | 46.24 | 11.83 | 165 | 5 |
Zhang et al. [77] | 2008 | China | Asian | 0.39 | No | 1.45 | 0.31 | 46 | 1.41 | 0.23 | 78 | 2.03 | 0.47 | 16 | 6 |
Wang et al. [78] | 2008 | China | Asian | 0.44 | Yes | 1.31 | 0.38 | 66 | 1.39 | 0.38 | 98 | 1.61 | 0.44 | 41 | 6 |
Qiu et al. [79] | 2009 | China | Asian | 0.41 | Yes | 1.18 | 0.36 | 38 | 1.25 | 0.33 | 32 | 1.28 | 0.42 | 21 | 6 |
Tao et al. [80] | 2010 | China | Asian | 0.41 | Yes | 0.95 | 0.19 | 608 | 0.96 | 0.18 | 939 | 0.97 | 0.18 | 272 | 6 |
Kappelle et al. [81] | 2013 | The Netherlands | Caucasian | 0.42 | Yes | 1.28 | 0.37 | 2301 | 1.35 | 0.40 | 3233 | 1.41 | 0.42 | 1246 | 6 |
Li et al. [82] | 2014 | China | Asian | 0.33 | Yes | 0.99 | 0.23 | 82 | 1.10 | 0.32 | 73 | 1.10 | 0.27 | 21 | 6 |
Galati et al. [83] | 2014 | Italia | Caucasian | 0.42 | Yes | 1.52 | 0.45 | 73 | 1.45 | 0.30 | 106 | 1.61 | 0.42 | 39 | 7 |
El-Aziz et al. [50] | 2014 | Egypt | Caucasian | 0.49 | Yes | 0.81 | 0.11 | 68 | 1.14 | 0.21 | 117 | 1.53 | 0.19 | 62 | 6 |
Zhai et al. [84] | 2015 | China | Asian | 0.48 | Yes | 0.96 | 0.28 | 12 | 1.10 | 0.25 | 34 | 1.12 | 0.31 | 14 | 6 |
Jeenduang et al. [85] | 2015 | Thailand | Asian | 0.37 | Yes | 1.34 | 0.32 | 152 | 1.35 | 0.35 | 169 | 1.39 | 0.31 | 57 | 6 |
Position | Size (Case/Control) | Allele Model | Additive Model | Recessive Model | Dominant Model | ||||
---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p Value | OR (95% CI) | p Value | OR (95% CI) | p Value | OR (95% CI) | p Value | ||
Overall analysis | 20,866/21,298 | 1.15 (1.09–1.21) | p < 0.001 | 1.26 (1.19–1.34) | p < 0.001 | 1.13 (1.08–1.18) | p < 0.001 | 1.20 (1.14–1.27) | p < 0.001 |
Subgroup analysis based on ethnicity | |||||||||
Asian | 5178/5084 | 1.24 (1.15–1.35) | p < 0.001 | 1.52 (1.35–1.72) | p < 0.001 | 1.41 (1.29–1.53) | p < 0.001 | 1.28 (1.15–1.42) | p < 0.001 |
Caucasian | 15,688/16,214 | 1.09 (1.04–1.16) | 0.001 | 1.19 (1.11–1.27) | p < 0.001 | 1.05 (1.00–1.11) | 0.041 | 1.18 (1.11–1.25) | p < 0.001 |
Subgroup analysis based on type of diseases | |||||||||
MI | 9067/9393 | 1.10 (1.03–1.19) | 0.009 | 1.18 (1.08–1.29) | p < 0.001 | 1.05 (0.99–1.12) | 0.104 | 1.17 (1.08–1.26) | p < 0.001 |
IS | 531/556 | 1.39 (1.17–1.66) | p < 0.001 | 1.92 (1.33–2.77) | 0.001 | 1.40 (1.09–1.79) | p < 0.001 | 1.76 (1.25–2.47) | 0.001 |
CAD | 11,268/11,349 | 1.15 (1.08–1.24) | p < 0.001 | 1.31 (1.21–1.43) | p < 0.001 | 1.19 (1.12–1.27) | p < 0.001 | 1.21 (1.13–1.31) | p < 0.001 |
Subgroup analysis based on source of controls | |||||||||
PB | 14,735/11,618 | 1.11 (1.05–1.17) | p < 0.001 | 1.21 (1.13–1.29) | p < 0.001 | 1.09 (1.04–1.15) | 0.001 | 1.17 (1.10–1.25) | p < 0.001 |
HB | 6131/5180 | 1.20 (1.10–1.31) | p < 0.001 | 1.42 (1.26–1.59) | p < 0.001 | 1.24 (1.14–1.35) | p < 0.001 | 1.28 (1.16–1.42) | p < 0.001 |
Subgroup analysis based on study type | |||||||||
CCS | 15,155/15,187 | 1.14 (1.10–1.18) | p < 0.001 | 1.30 (1.21–1.39) | p < 0.001 | 1.16 (1.11–1.22) | p < 0.001 | 1.22 (1.15–1.30) | p < 0.001 |
CS | 5711/6111 | 1.07 (1.01–1.13) | 0.023 | 1.16 (1.03–1.30) | 0.012 | 1.05 (0.97–1.14) | 0.277 | 1.15 (1.04–1.28) | 0.007 |
Sensitivity analysis | |||||||||
BHWE | 14,461/16,034 | 1.16 (1.09–1.23) | p < 0.001 | 1.33 (1.23–1.42) | p < 0.001 | 1.18 (1.12–1.24) | p < 0.001 | 1.24 (1.16–1.32) | p < 0.001 |
BS | 18,902/19,454 | 1.12 (1.08–1.15) | p < 0.001 | 1.25 (1.18–1.33) | p < 0.001 | 1.13 (1.08–1.18) | p < 0.001 | 1.20 (1.14–1.27) | p < 0.001 |
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Guo, S.-x.; Yao, M.-h.; Ding, Y.-s.; Zhang, J.-y.; Yan, Y.-z.; Liu, J.-m.; Zhang, M.; Rui, D.-s.; Niu, Q.; He, J.; et al. Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis. Int. J. Environ. Res. Public Health 2016, 13, 882. https://doi.org/10.3390/ijerph13090882
Guo S-x, Yao M-h, Ding Y-s, Zhang J-y, Yan Y-z, Liu J-m, Zhang M, Rui D-s, Niu Q, He J, et al. Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis. International Journal of Environmental Research and Public Health. 2016; 13(9):882. https://doi.org/10.3390/ijerph13090882
Chicago/Turabian StyleGuo, Shu-xia, Ming-hong Yao, Yu-song Ding, Jing-yu Zhang, Yi-zhong Yan, Jia-ming Liu, Mei Zhang, Dong-sheng Rui, Qiang Niu, Jia He, and et al. 2016. "Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis" International Journal of Environmental Research and Public Health 13, no. 9: 882. https://doi.org/10.3390/ijerph13090882