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Int. J. Environ. Res. Public Health 2016, 13(9), 837; doi:10.3390/ijerph13090837

Evaluation of the Accuracy of Capillary Hydroxybutyrate Measurement Compared with Other Measurements in the Diagnosis of Diabetic Ketoacidosis: A Systematic Review

1
College of Nursing, Midwifery and Healthcare, University of West London, Boston Manor Road Brentford, Middlesex TW8 9GA, UK
2
Faculty of Education and Health, University of Greenwich, Avery Hill Campus, London SE9 2UG, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 18 June 2016 / Revised: 13 August 2016 / Accepted: 17 August 2016 / Published: 23 August 2016
(This article belongs to the Collection Health Care and Diabetes)
View Full-Text   |   Download PDF [274 KB, uploaded 23 August 2016]

Abstract

A complication of diabetes is diabetic ketoacidosis (DKA), which if left untreated is a life threatening condition. Prompt and accurate diagnosis of DKA is required for the commencement of life saving interventions. Measurements of ketone bodies in DKA have usually been through nitroprusside urine acetoacetate testing. The aim of this systematic review was to examine whether capillary β-hydroxybutyrate (β-OHB) testing is more accurate compared to other diagnostic methods of DKA. The following electronic databases were searched: EBSCO Host, MEDLINE, PSYCHInfo, CINAHL and Science Direct for publications from 1 January 2005 and up to and including 1 January 2016. Inclusion criteria were: Adults 18 years and over and known type 1 or type 2 diabetes. Retrospective and prospective observation studies were included. A total of nine studies met the inclusion criteria. Capillary β-OHB was found to have high sensitivity, specificity, positive predictive value and negative predictive value in identifying DKA compared to urinary ketone testing. View Full-Text
Keywords: diabetes ketoacidosis; type 1 diabetes; type 2 diabetes; emergency department; point of care testing; ketones diabetes ketoacidosis; type 1 diabetes; type 2 diabetes; emergency department; point of care testing; ketones
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Brooke, J.; Stiell, M.; Ojo, O. Evaluation of the Accuracy of Capillary Hydroxybutyrate Measurement Compared with Other Measurements in the Diagnosis of Diabetic Ketoacidosis: A Systematic Review. Int. J. Environ. Res. Public Health 2016, 13, 837.

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