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Int. J. Environ. Res. Public Health 2016, 13(8), 803; doi:10.3390/ijerph13080803

PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population

1
Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico
2
Department of Endocrinology, National Institute of Cardiology “Ignacio Chávez”, Mexico City 14080, Mexico
3
Community Health Research Department, Children’s Hospital of Mexico “Federico Gomez”, Ministry of Health (SSA), Mexico City 06720, Mexico
4
Juarez Autonomous University of Tabasco, Multidisciplinary Academic Division of Comacalco, Villahermosa 86040, Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 20 May 2016 / Revised: 17 July 2016 / Accepted: 1 August 2016 / Published: 9 August 2016
View Full-Text   |   Download PDF [287 KB, uploaded 9 August 2016]

Abstract

Single-nucleotide polymorphisms (SNPs) in the protein phosphatase and actin regulator 1 gene (PHACTR1) have been associated with susceptibility to develop several diseases, including cardiovascular disease. The purpose of this study was to evaluate the role of two polymorphisms (rs2026458 and rs9349379) of the PHACTR1 gene in the susceptibility to the risk of developing premature coronary artery disease (CAD) in the Mexican population. The genotype analysis was performed using 5’exonuclease TaqMan genotyping assays in a group of 994 patients with premature CAD and 703 controls. A similar genotype distribution of rs2026458 was observed in both groups; however, under an additive model adjusted by age, body mass index, type 2 diabetes mellitus, smoking, dyslipidemia, and hypertension, the rs9349379 G allele was associated with a higher risk for developing premature CAD (odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.03–1.46, p-value (p) = 0.024). The two PHACTR1 polymorphisms were not in linkage disequilibrium. In summary, our results suggest that the PHACTR1 rs9349379 polymorphism plays an important role in the risk of developing premature CAD in the Mexican population. View Full-Text
Keywords: coronary artery disease; genetic polymorphisms; vascular calcification; PHACTR1 gene coronary artery disease; genetic polymorphisms; vascular calcification; PHACTR1 gene
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Pérez-Hernández, N.; Vargas-Alarcón, G.; Posadas-Sánchez, R.; Martínez-Rodríguez, N.; Tovilla-Zárate, C.A.; Rodríguez-Cortés, A.A.; Pérez-Méndez, O.; Blachman-Braun, R.; Rodríguez-Pérez, J.M. PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population. Int. J. Environ. Res. Public Health 2016, 13, 803.

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