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Int. J. Environ. Res. Public Health 2016, 13(5), 477; doi:10.3390/ijerph13050477

H-Type Hypertension and C Reactive Protein in Recurrence of Ischemic Stroke

1
Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China
2
Guangming New District People’s Hospital & Community Health Service Management Center of Guangming Area, Shenzhen 518000, China
3
Internal Medicine-Neurology, Huaihe Hospital, Henan University, Kaifeng 475000, China
4
Basical School, Guangzhou Medical University, Guangzhou 510180, China
5
Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou 510180, China
6
Department of Public Health, School of Public Health, Graduate School of Guizhou Medical University, Guiyang 550025, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 7 March 2016 / Revised: 27 April 2016 / Accepted: 4 May 2016 / Published: 7 May 2016
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Abstract

Hypertension with high homocysteine (HHcy) (H-type hypertension) and C reactive protein (CRP) can increase the incidence of ischemic stroke. However, it is not clear whether recurrent ischemic stroke (RIS) is related to H-type hypertension and CRP. The present study investigated the correlation of H-type hypertension and CRP level with RIS. Totally, 987 consecutive patients with acute ischemic stroke were recruited in a teaching hospital in Henan province, China during March 2014 to March 2015. The demographic and clinical characteristics and blood biochemical parameters of patients were analyzed. Elevated levels of CRP and homocysteine (Hcy) were defined as >8.2 mg/L and 10 μmol/L, respectively. Among the 987 patients, 234 were RIS. Thirty-eight percent of RIS patients had elevated CRP level and 91.5% of RIS patients had HHcy. In multivariate analysis, adjusted odds ratio (OR) of RIS in patients aged ≥60 years was 1.576 (95% CI: 1.125–2.207), in male patients 1.935 (95% CI: 1.385–2.704), in patients with diabetes 1.463 (95% CI: 1.037–2.064), CRP levels 1.013 (95% CI: 1.006–1.019), simple hypertension 3.370 (95% CI: 1.15–10.183), and H-type hypertension 2.990 (95% CI: 1.176–7.600). RIS was associated with older age, male, diabetes, H-type hypertension and CRP. Controlling H-type hypertension and CRP level may reduce the risk of RIS. View Full-Text
Keywords: C reactive protein; H-type hypertension; recurrence ischemic stroke C reactive protein; H-type hypertension; recurrence ischemic stroke
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MDPI and ACS Style

Zhang, Q.; Qiu, D.-X.; Fu, R.-L.; Xu, T.-F.; Jing, M.-J.; Zhang, H.-S.; Geng, H.-H.; Zheng, L.-C.; Wang, P.-X. H-Type Hypertension and C Reactive Protein in Recurrence of Ischemic Stroke. Int. J. Environ. Res. Public Health 2016, 13, 477.

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