Next Article in Journal
Life Course, Green Space and Health: Incorporating Place into Life Course Epidemiology
Previous Article in Journal
Dose-Response Relationship between Cumulative Occupational Lead Exposure and the Associated Health Damages: A 20-Year Cohort Study of a Smelter in China
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2016, 13(3), 330; doi:10.3390/ijerph13030330

Assessment of Environmental and Hereditary Influence on Development of Pituitary Tumors Using Dermatoglyphic Traits and Their Potential as Screening Markers

1
County Hospital Cakovec, I.G. Kovacica 1E, 40000 Cakovec, Croatia
2
Department of Endocrinology, University Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia
3
Faculty of Medicine, University Josip JurajStrossmayer, Department of Pharmacology, Clinical Hospital Center Osijek, 31000 Osijek, Croatia
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 28 November 2015 / Revised: 15 February 2016 / Accepted: 18 February 2016 / Published: 17 March 2016
View Full-Text   |   Download PDF [280 KB, uploaded 17 March 2016]

Abstract

The aim of this study was to assess environmental and hereditary influence on development of pituitary tumors using dermatoglyphic traits. The study was performed on 126 patients of both genders with pituitary tumors (60 non-functional and 66 functional pituitary tumor patients) in comparison to the control group of 400 phenotypically healthy individuals. Statistical analysis of quantitative and qualitative traits of digito-palmar dermatoglyphics was performed, and hormonal status was determined according to the standard protocols. Although we did not find markers that could specifically distinguish functional from non-functional tumors, we have found markers predisposing to the development of tumors in general (a small number of ridges between triradius of both hands, a smaller number of ridges between the triradius of c–d rc R), those for endocrine dysfunction (increased number of arches and reduced number of whorls, difference of pattern distribution in the I3 and I4 interdigital space), and some that could potentially be attributed to patients suffering from pituitary tumors (small number of ridges for variables FRR 5, smaller number of ridges in the FRL 4 of both hands and difference of pattern distribution at thenar of I1 and I2 interdigital space). The usage of dermatoglyphic traits as markers of predisposition of pituitary tumor development could facilitate the earlier detection of patients in addition to standard methods, and possibly earlier treatment and higher survival rate. Finally, our results are consistent with the hypothesis about multifactorial nature of pituitary tumor etiology comprised of both gene instability and environmental factors. View Full-Text
Keywords: dermatoglyphic traits; functional pituitary tumors; non-functional pituitary tumors; early detection; multifactorial etiology dermatoglyphic traits; functional pituitary tumors; non-functional pituitary tumors; early detection; multifactorial etiology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gradiser, M.; Matovinovic Osvatic, M.; Dilber, D.; Bilic-Curcic, I. Assessment of Environmental and Hereditary Influence on Development of Pituitary Tumors Using Dermatoglyphic Traits and Their Potential as Screening Markers. Int. J. Environ. Res. Public Health 2016, 13, 330.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top