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Int. J. Environ. Res. Public Health 2016, 13(11), 1133; doi:10.3390/ijerph13111133

The Association between Alcohol Consumption and β-Cell Function and Insulin Sensitivity in Korean Population

Center for Biomedical Sciences, Korea National Institute of Health, Cheongju 28159, Korea
These authors contributed equally to this work.
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Academic Editor: Icro Maremmani
Received: 1 September 2016 / Revised: 20 October 2016 / Accepted: 27 October 2016 / Published: 14 November 2016
(This article belongs to the Section Global Health)
View Full-Text   |   Download PDF [318 KB, uploaded 14 November 2016]

Abstract

This cross-sectional study was performed to examine the association between alcohol consumption and insulin secretion and sensitivity using the Korean Genome and Epidemiology Study. Alcohol consumption levels were categorized into four groups: (i) abstainers, (ii) low (<5 g/day), (iii) intermediate (<30 g/day), and (iv) high (≥30 g/day) alcohol consumption. β-cell function and insulin sensitivity were estimated using the insulinogenic index (IGI60), and Matsuda insulin sensitivity index (ISI), respectively. IGI60 and ISI were dichotomized into high and low groups using median cut-off values and four groups were defined (G-I: high IGI60/high ISI; G-II: high IGI60/low ISI; G-III: low IGI60/high ISI; and G-IV: low IGI60/low ISI). Men consumed 26.5 g alcohol per day on average, whereas women only consumed 5.7 g/day, so women were excluded from subsequent analyses due to their low drinking levels. Alcohol consumption was positively associated with high-density lipoprotein (HDL) cholesterol, aspartate aminotransferase (AST), and triglycerides (TG) in men, but was negatively associated with IGI60 (p < 0.05). TG levels were only increased in individuals with decreased insulin sensitivity (G-II) or decreased β-cell function (G-III) with high alcohol consumption. In addition, alcohol consumption increased HDL cholesterol in the four groups (p < 0.001). In subjects with decreased insulin sensitivity (G-II), intermediate and high alcohol consumption increased the risk of high cholesterol and TG. In individuals with decreased β-cell function (G-III), alcohol consumption increased the risk of high TG and high AST levels. High alcohol consumption was significantly associated with reduced insulin secretion. In addition, alcohol consumption was related to some metabolic risk factors depending on insulin secretion or sensitivity. View Full-Text
Keywords: alcohol consumption; insulin sensitivity; β-cell function; hypertriglyceridemia alcohol consumption; insulin sensitivity; β-cell function; hypertriglyceridemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yoo, M.-G.; Kim, H.-J.; Jang, H.B.; Lee, H.-J.; Park, S.I. The Association between Alcohol Consumption and β-Cell Function and Insulin Sensitivity in Korean Population. Int. J. Environ. Res. Public Health 2016, 13, 1133.

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