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Int. J. Environ. Res. Public Health 2016, 13(11), 1103; doi:10.3390/ijerph13111103

Independent Factors of Changes of Ankle-Brachial Index in Peripheral Arterial Occlusive Disease in Elderly Patients with or without Diabetes

1
Faculty of Health Sciences, University of Bielsko-Biala, 43-309 Bielsko-Biala, Poland
2
Department of Gerontology and Geriatric Nursing, School of Health Sciences, Medical University of Silesia, 40-752 Katowice, Poland
3
Department of Nursing Propaedeutics, School of Health Sciences, Medical University of Silesia, 40-752 Katowice, Poland
4
Department of Clinical Nursing Faculty of Health Sciences, Medical University, 50-367 Wroclaw, Poland
5
Department of Rehabilitation, Medical University, Provincial Hospital in Bielsko-Biala, 43-309 Bielsko-Biala, Poland
6
Specialist Psychiatric Health Care Center, 43-309 Bielsko-Biala, Poland
7
School of Health Sciences in Katowice, Medical University of Silesia, Chair of Woman’s Health, 40-752 Katowice, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Omorogieva Ojo
Received: 24 May 2016 / Revised: 15 October 2016 / Accepted: 30 October 2016 / Published: 8 November 2016
(This article belongs to the Collection Health Care and Diabetes)
View Full-Text   |   Download PDF [441 KB, uploaded 8 November 2016]   |  

Abstract

Peripheral arterial disease (PAD) belongs to the commonly-occurring pathologies associated with elderly age. A simple tool for defining the severity of PAD is the ankle-brachial index (ABI). The purpose of this research was to determine independent factors of changes of ABI in elderly patients with occlusive PAD disease (PAOD) with and without diabetes. The research was carried out on 49 elderly patients with PAOD, including 29 patients with type 2 diabetes, and 20 patients without diabetes. The concentration of interleukin-6 (IL-6), E-selectin, fibrinogen, and C-reactive protein (CRP) in the blood serum was marked. In all patients, the independent factors of changes of ABI were determined with the use of the multiple logistic regression analysis. Our results show that in the group of patients with PAOD suffering from diabetes, it was demonstrated that the ABI was related to age, the duration of the symptoms of PAD, body mass index (BMI), low-density lipoprotein cholesterol, fibrinogen, and sex (determination coefficient R2 = 0.699). In patients with PAOD without diabetes, the ABI was related to age, the duration of the symptoms of PAD, the levels of CRP, E-selectin, high-density lipoprotein cholesterol, and the glomerular filtration rate(determination coefficient R2 = 0.844). We conclude that in elderly patients with PAOD with and without diabetes, the participation of independent factors related to the ABI is diversified; in patients with diabetes, the concentration of IL-6 and fibrinogen is lower, and the concentration of E-selectin is higher than in patients without diabetes. View Full-Text
Keywords: ankle-brachial index; peripheral arterial disease; diabetes; elderly ankle-brachial index; peripheral arterial disease; diabetes; elderly
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MDPI and ACS Style

Bąk, E.; Marcisz, C.; Kadłubowska, M.; Michalik, A.; Krawczyk, B.; Dobrzyń-Matusiak, D.; Krzemińska, S.; Fiałkowski, T.; Glądys, E.; Drosdzol-Cop, A. Independent Factors of Changes of Ankle-Brachial Index in Peripheral Arterial Occlusive Disease in Elderly Patients with or without Diabetes. Int. J. Environ. Res. Public Health 2016, 13, 1103.

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