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Int. J. Environ. Res. Public Health 2016, 13(10), 990; doi:10.3390/ijerph13100990

Low Dose Cadmium Inhibits Proliferation of Human Renal Mesangial Cells via Activation of the JNK Pathway

1
Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan 250014, China
2
Key Laboratory of Molecular and Nano Probes, Ministry of Education, College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China
3
Taishan Medical College, Taian 271000, China
4
Department of Nephrology, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan 250014, China
5
Department of Biology, Trent University, Peterborough, ON K9L0G2, Canada
*
Author to whom correspondence should be addressed.
Received: 23 July 2016 / Accepted: 29 September 2016 / Published: 7 October 2016
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Abstract

Cadmium (Cd) is a heavy metal and environmental pollutant. The kidney is the principal target organ of Cd exposure. Previously, we found that low concentration of Cd damages the integrity of the glomerular filtration barrier. However, little is known about the effects of Cd on renal mesangial cells, which provide structural support for the glomerular capillary loops and regulate intraglomerular blood flow. In this study, human renal mesangial cells (HRMCs) were cultured in the presence of serum and treated with 4 μM Cd. We found that Cd activates the c-Jun N-terminal kinase (JNK) pathway, and increases the protein levels of c-Jun and c-Fos. Cd treatment also induces a decrease in proliferation and an increase in apoptosis of HRMCs, but only the decrease in HRMC proliferation was reversed by pretreatment with SP600125, an inhibitor of the JNK pathway. In addition, Cd does not change the expression of α-smooth muscle actin and platelet-derived growth factor receptor-β, the markers of mesangial cells, or the alignment of the filamentous actin (F-actin) cytoskeleton of HRMCs. Our data indicate that the JNK pathway mediates the inhibitory effects of Cd on HRMC proliferation. View Full-Text
Keywords: cadmium; renal mesangial cells; JNK pathway; proliferation cadmium; renal mesangial cells; JNK pathway; proliferation
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MDPI and ACS Style

Chen, X.; Li, J.; Cheng, Z.; Xu, Y.; Wang, X.; Li, X.; Xu, D.; Kapron, C.M.; Liu, J. Low Dose Cadmium Inhibits Proliferation of Human Renal Mesangial Cells via Activation of the JNK Pathway. Int. J. Environ. Res. Public Health 2016, 13, 990.

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