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Int. J. Environ. Res. Public Health 2016, 13(10), 939; doi:10.3390/ijerph13100939

Polymorphisms in GEMIN4 and AGO1 Genes Are Associated with the Risk of Lung Cancer: A Case-Control Study in Chinese Female Non-Smokers

1,2
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1,2
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1,2
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1,2
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1,2,*
1
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China
2
Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110122, China
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 17 July 2016 / Revised: 6 September 2016 / Accepted: 19 September 2016 / Published: 23 September 2016
View Full-Text   |   Download PDF [431 KB, uploaded 23 September 2016]   |  

Abstract

MicroRNA biosynthesis genes can affect the regulatory effect of global microRNAs to target mRNA and hence influence the genesis and development of human cancer. Here, we selected five single nucleotide polymorphisms (SNPs) (rs7813, rs2740349, rs2291778, rs910924, rs595961) in two key microRNA biosynthesis genes (GEMIN4 and AGO1) and systematically evaluated the association between these SNPs, the gene-environment interaction and lung cancer risk. To control the impact of cigarette smoking on lung cancer, we recruited Chinese female non-smokers for the study. The total number of lung cancer cases and cancer-free controls were 473 and 395 in the case-control study. Four SNPs showed statistically significant associations with lung cancer risk. After Bonferroni correction, rs7813 and rs595961 were evidently still associated with lung cancer risk. In the stratified analysis, our results revealed that all five SNPs were associated with the risk of lung adenocarcinoma; after Bonferroni correction, significant association was maintained for rs7813, rs910924 and rs595961. Haplotype analysis showed GEMIN4 haplotype C-A-G-T was a protective haplotype for lung cancer. In the combined unfavorable genotype analysis, with the increasing number of unfavorable genotypes, a progressively increased gene-dose effect was observed in lung adenocarcinoma. We also found that individuals exposed to cooking oil fumes showed a relatively high risk of lung cancer, but no interactions were found between cooking oil fume exposure or passive smoking exposure with these SNPs, either on an additive scale or a multiplicative scale. Overall, this is the first study showing that rs7813 and rs595961 could be meaningful as genetic markers for lung cancer risk. View Full-Text
Keywords: GEMIN4; AGO1; single nucleotide polymorphism; lung cancer; susceptibility; cooking oil fumes; passive smoking GEMIN4; AGO1; single nucleotide polymorphism; lung cancer; susceptibility; cooking oil fumes; passive smoking
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Fang, X.; Yin, Z.; Li, X.; Xia, L.; Zhou, B. Polymorphisms in GEMIN4 and AGO1 Genes Are Associated with the Risk of Lung Cancer: A Case-Control Study in Chinese Female Non-Smokers. Int. J. Environ. Res. Public Health 2016, 13, 939.

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