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Int. J. Environ. Res. Public Health 2016, 13(10), 1031; doi:10.3390/ijerph13101031

Zika Virus Infection and Microcephaly: Evidence for a Causal Link

Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China
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Academic Editor: Paul B. Tchounwou
Received: 8 September 2016 / Revised: 17 October 2016 / Accepted: 18 October 2016 / Published: 20 October 2016
View Full-Text   |   Download PDF [270 KB, uploaded 20 October 2016]

Abstract

Zika virus (ZIKV) is a flavivirus related to the Dengue, yellow fever and West Nile viruses. Since the explosive outbreaks of ZIKV in Latin America in 2015, a sudden increase in the number of microcephaly cases has been observed in infants of women who were pregnant when they contracted the virus. The severity of this condition raises grave concerns, and extensive studies on the possible link between ZIKV infection and microcephaly have been conducted. There is substantial evidence suggesting that there is a causal link between ZIKV and microcephaly, however, future studies are warranted to solidify this association. To summarize the most recent evidence on this issue and provide perspectives for future studies, we reviewed the literature to identify existing evidence of the causal link between ZIKV infection and microcephaly within research related to the epidemics, laboratory diagnosis, and possible mechanisms. View Full-Text
Keywords: Zika virus (ZIKV); microcephaly; pregnancy; fetus Zika virus (ZIKV); microcephaly; pregnancy; fetus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, J.-N.; Ling, F. Zika Virus Infection and Microcephaly: Evidence for a Causal Link. Int. J. Environ. Res. Public Health 2016, 13, 1031.

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