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Int. J. Environ. Res. Public Health 2016, 13(1), 86;

Adverse Events in Treating Smear-Positive Tuberculosis Patients in China

Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China
Clinical Center Office, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA 01702-5827, USA
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 12 October 2015 / Revised: 17 December 2015 / Accepted: 23 December 2015 / Published: 29 December 2015
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This study aimed to estimate the adverse events (AE) rate during anti-tuberculosis treatment and to explore AE-related risk factors. New and previously treated smear-positive tuberculosis (TB) cases were enrolled from eight regions in China between April 2009 and October 2010. The AE rate was estimated, and AE risk factors during anti-TB treatment were assessed using Cox proportional models. Among 2091 Chinese subjects with anti-TB treatment, 462 (22.1%, 95% confidence interval (CI), 20.3–23.9) patients developed AE, with liver injury and gastrointestinal reactions constituting the most common AE. Specifically, 9.8% (95% CI, 8.5–11.1) and 6.3% (95% CI, 5.3–7.4) developed liver injuries and gastrointestinal reactions, respectively. We found that AE rate differed by regions, TB knowledge score, symptoms score and smoking status. Liver injuries were associated with age, sex and smoking status; gastrointestinal reactions were associated with education level and symptom score. Improving patients’ knowledge on TB could reduce AE rate. View Full-Text
Keywords: adverse events; tuberculosis epidemiology; risk factors; China adverse events; tuberculosis epidemiology; risk factors; China

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Zhang, T.; Du, J.; Yin, X.; Xue, F.; Liu, Y.; Li, R.; Luo, C.; Li, L.; Li, X. Adverse Events in Treating Smear-Positive Tuberculosis Patients in China. Int. J. Environ. Res. Public Health 2016, 13, 86.

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