Next Article in Journal
Electronic Cigarettes on Hospital Campuses
Previous Article in Journal
Medical Hydrogeology of Asian Deltas: Status of Groundwater Toxicants and Nutrients, and Implications for Human Health
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2016, 13(1), 86; doi:10.3390/ijerph13010086

Adverse Events in Treating Smear-Positive Tuberculosis Patients in China

1
Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China
2
Clinical Center Office, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
3
Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
4
National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA 01702-5827, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 12 October 2015 / Revised: 17 December 2015 / Accepted: 23 December 2015 / Published: 29 December 2015
View Full-Text   |   Download PDF [433 KB, uploaded 29 December 2015]   |  

Abstract

This study aimed to estimate the adverse events (AE) rate during anti-tuberculosis treatment and to explore AE-related risk factors. New and previously treated smear-positive tuberculosis (TB) cases were enrolled from eight regions in China between April 2009 and October 2010. The AE rate was estimated, and AE risk factors during anti-TB treatment were assessed using Cox proportional models. Among 2091 Chinese subjects with anti-TB treatment, 462 (22.1%, 95% confidence interval (CI), 20.3–23.9) patients developed AE, with liver injury and gastrointestinal reactions constituting the most common AE. Specifically, 9.8% (95% CI, 8.5–11.1) and 6.3% (95% CI, 5.3–7.4) developed liver injuries and gastrointestinal reactions, respectively. We found that AE rate differed by regions, TB knowledge score, symptoms score and smoking status. Liver injuries were associated with age, sex and smoking status; gastrointestinal reactions were associated with education level and symptom score. Improving patients’ knowledge on TB could reduce AE rate. View Full-Text
Keywords: adverse events; tuberculosis epidemiology; risk factors; China adverse events; tuberculosis epidemiology; risk factors; China
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhang, T.; Du, J.; Yin, X.; Xue, F.; Liu, Y.; Li, R.; Luo, C.; Li, L.; Li, X. Adverse Events in Treating Smear-Positive Tuberculosis Patients in China. Int. J. Environ. Res. Public Health 2016, 13, 86.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top