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Int. J. Environ. Res. Public Health 2015, 12(9), 11528-11548; doi:10.3390/ijerph120911528

Serum Adiponectin and Leptin Concentrations in Relation to Body Fat Distribution, Hematological Indices and Lipid Profile in Humans

1
Department of Functional Diagnostics and Physical Medicine, Faculty of Health Sciences, Pomeranian Medical University in Szczecin
2
Department of Medical Rehabilitation, Faculty of Health Sciences, Pomeranian Medical University in Szczecin
3
Department of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University in Szczecin
4
Department of Physiology, Faculty of Biology, Szczecin University, ul. Felczaka 3c, 71–412 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 12 June 2015 / Revised: 11 August 2015 / Accepted: 19 August 2015 / Published: 14 September 2015
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Abstract

The purpose of the study was to evaluate the relationship between serum adiponectin and leptin concentrations and body composition, hematological indices and lipid profile parameters in adults. The study involved 95 volunteers (BMI from 23.3 to 53 kg/m2). Anthropometric parameters were measured: body weight and height, waist and hip circumference, waist-to-hip ratio, body fat mass (BMF), subcutaneous and visceral fat mass (SFM, VFM), lean body mass (LBM), skeletal muscle mass (SMM). In serum we determined adiponectin and leptin concentrations, extracellular hemoglobin, total bilirubin, as well as lipid metabolism (TCh, HDL-Ch, LDL-Ch, TG). Mean adipokine levels were significantly higher in women (p ≤ 0.01), adiponectin significantly negatively correlated with body height and weight, systolic blood pressure and absolute LBM and SMM values. The same relation was observed for erythroid system indicators and lipid indicators. A positive correlation was exceptionally found between adiponectin and HDL-Ch. LEP negatively correlated with some percentage rates (%LBM, %SMM). Only in women, we observed a positive correlation between LEP and body weight, BMI and WHR. Studies on ADPN and the ADPN/LEP ratio as a valuable complementary diagnostic element in the prediction and prevention of cardiovascular diseases need to be continued. View Full-Text
Keywords: adiponectin; leptin; ADPN/LEP ratio; lipid profile; body mass components adiponectin; leptin; ADPN/LEP ratio; lipid profile; body mass components
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lubkowska, A.; Radecka, A.; Bryczkowska, I.; Rotter, I.; Laszczyńska, M.; Dudzińska, W. Serum Adiponectin and Leptin Concentrations in Relation to Body Fat Distribution, Hematological Indices and Lipid Profile in Humans. Int. J. Environ. Res. Public Health 2015, 12, 11528-11548.

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