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Int. J. Environ. Res. Public Health 2015, 12(9), 10549-10557; doi:10.3390/ijerph120910549

Effective Strategies for Monitoring and Regulating Chemical Mixtures and Contaminants Sharing Pathways of Toxicity

Center for Environmental Security, The Biodesign Institute, Global Security Initiative, Arizona State University, Tempe, AZ 85287, USA
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Author to whom correspondence should be addressed.
Academic Editor: Oladele A. Ogunseitan
Received: 26 June 2015 / Revised: 31 July 2015 / Accepted: 25 August 2015 / Published: 28 August 2015
(This article belongs to the Special Issue Hazardous Waste and Human Health)
View Full-Text   |   Download PDF [638 KB, uploaded 28 August 2015]   |  

Abstract

Traditionally, hazardous chemicals have been regulated in the U.S. on a one-by-one basis, an approach that is slow, expensive and can be inefficient, as illustrated by a decades-long succession of replacing one type of organohalogen flame retardants (OHFRs) with another one, without addressing the root cause of toxicity and associated public health threats posed. The present article expounds on the need for efficient monitoring strategies and pragmatic steps in reducing environmental pollution and adverse human health impacts. A promising approach is to combine specific bioassays with state-of-the-art chemical screening to identify chemicals and chemical mixtures sharing specific modes of action (MOAs) and pathways of toxicity (PoTs). This approach could be used to identify and regulate hazardous chemicals as classes or compound families, featuring similar biological end-points, such as endocrine disruption and mutagenicity. Opportunities and potential obstacles of implementing this approach are discussed. View Full-Text
Keywords: environmental monitoring; flame retardants; regulatory framework; chemical mixtures; toxicity environmental monitoring; flame retardants; regulatory framework; chemical mixtures; toxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Venkatesan, A.K.; Halden, R.U. Effective Strategies for Monitoring and Regulating Chemical Mixtures and Contaminants Sharing Pathways of Toxicity. Int. J. Environ. Res. Public Health 2015, 12, 10549-10557.

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