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Int. J. Environ. Res. Public Health 2015, 12(7), 8023-8033; doi:10.3390/ijerph120708023

Matrix Metalloproteinase 9 Gene Promoter (rs 3918242) Mutation Reduces the Risk of Diabetic Microvascular Complications

1
Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan 250014, China
2
Division of Endocrinology, Department of Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China
3
Department of Cadres Healthcare, Qilu Hospital of Shandong University, Qingdao 266035, China
4
Division of Endocrinology, Department of Medicine, Qilu Hospital of Shandong University, Jinan 250012, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 27 May 2015 / Revised: 5 July 2015 / Accepted: 7 July 2015 / Published: 14 July 2015
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Abstract

Background: Many studies have evaluated the association between matrix metalloproteinase 9 (MMP9) gene promoter polymorphism and diabetic microvascular complications. However, the results are conflicting and inconclusive. The aim of this meta-analysis was to evaluate the association more precisely. Materials and Methods: Studies were retrieved from the PubMed, Embase, Medline, China National Knowledge Infrastructure, Web of Science, and Cochrane databases. All statistical analyses were performed using Review Manager 5.2. Results: Data were abstracted from four case-control studies that included 446 patients with diabetic microvascular complications and 496 diabetic control subjects. The MMP9-1562 C/T genotype was significantly associated with the risk of diabetic nephropathy after stratification by specific type of microvascular complication (CT + TT vs. CC: OR = 0.42, 95% CI = 0.26–0.69, p = 0.0006; TT vs. CC + CT: OR = 0.37, 95% CI = 0.19–0.76, p = 0.006). Conclusions: This study adds to the evidence that MMP9-1562 T gene mutation might reduce the risk of diabetic nephropathy. View Full-Text
Keywords: matrix metalloproteinase 9; diabetes mellitus; meta-analysis matrix metalloproteinase 9; diabetes mellitus; meta-analysis
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MDPI and ACS Style

Zhang, Z.; Wu, X.; Cai, T.; Gao, W.; Zhou, X.; Zhao, J.; Yao, J.; Shang, H.; Dong, J.; Liao, L. Matrix Metalloproteinase 9 Gene Promoter (rs 3918242) Mutation Reduces the Risk of Diabetic Microvascular Complications. Int. J. Environ. Res. Public Health 2015, 12, 8023-8033.

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