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Int. J. Environ. Res. Public Health 2015, 12(7), 7899-7909; doi:10.3390/ijerph120707899

Incidence Density and Risk Factors of Diabetic Retinopathy Within Type 2 Diabetes: A Five-Year Cohort Study in China (Report 1)

1
Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China
2
Department of Healthcenter, Fengyutan Community, Shenyang, 110014, China
3
Key Laboratory of Endocrine Diseases in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China
4
Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110122, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 26 May 2015 / Revised: 29 June 2015 / Accepted: 7 July 2015 / Published: 10 July 2015
View Full-Text   |   Download PDF [683 KB, uploaded 10 July 2015]

Abstract

A prospective study was carried out from August 2010 to August 2014 in the community of Fengyutan (China). Six hundred and twenty two T2D subjects were collected. The incidence density of diabetic retinopathy (DR) was 1.81% person-year (95% confidence interval, CI: 1.21–2.43% person-year). After a Cox regression model analysis and adjusted confounding factors, independent predictors related to the incidence of DR including male gender (adjusted hazard ratios, aHR: 1.47, 95% CI: 1.21–1.62), with hypertension (aHR: 1.49, 95%: 1.12–1.73), duration of diabetes > 10 years (aHR: 2.28, 95%: 2.05–2.42), uncontrolled diabetes (aHR: 1.76, 95%: 1.41–2.01), total cholesterol ≥ 200 mg/dL (aHR: 1.54, 95%: 1.34–1.72) and HbA1c ≥ 7% (mmol/mol) (aHR: 2.12, 95%: 1.87–2.32). Duration of T2D revealed the significantly dose-response relationship to the onset of DR. The incidence density of DR in the Chinese community was relatively low in comparison with other studies. More attention should be paid to the T2D patients, especially of male gender, with hypertension, longer duration of diabetes, uncontrolled diabetes, total cholesterol ≥ 200mg/dL and HbA1c ≥ 7% (mmol/mol). View Full-Text
Keywords: community; diabetic retinopathy; epidemiology; incidence density; risk factors community; diabetic retinopathy; epidemiology; incidence density; risk factors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Liu, L.; Wu, J.; Yue, S.; Geng, J.; Lian, J.; Teng, W.; Huang, D.; Chen, L. Incidence Density and Risk Factors of Diabetic Retinopathy Within Type 2 Diabetes: A Five-Year Cohort Study in China (Report 1). Int. J. Environ. Res. Public Health 2015, 12, 7899-7909.

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