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Int. J. Environ. Res. Public Health 2015, 12(11), 14229-14243; doi:10.3390/ijerph121114229

Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8

1
Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan
2
Department of Data Science, Institute of Statistical Mathematics, 10-3 Midori-cho, Tachikawa, Tokyo 190-8562, Japan
3
Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kinki University, Ohnohigashi 377-2, Osakasayama 589-0014, Japan
4
Board of Directors, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan
5
Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan
6
Department of Dermatology, Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
7
Chromosome Engineering Research Center, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 14 August 2015 / Revised: 29 October 2015 / Accepted: 30 October 2015 / Published: 9 November 2015
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Abstract

This study aimed to investigate the effects of particulate matter (PM) on pulmonary function in schoolchildren, as well as the relationships of these effects with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children during April–May 2012, and in 384 of these children during March–May 2013. PEF’s association with the daily levels of suspended particulate matter (SPM) and PM < 2.5 mm (PM2.5) was estimated using a linear mixed model. Interleukin-8 promoter activity was assessed in THP-G8 cells stimulated by fallen PM collected at Tottori University Hospital during four periods (two in 2012 and two in 2013). An increase of 14.0 mg/m3 in SPM led to PEF changes of −2.16 L/min in 2012 and −0.81 L/min in 2013, respectively. An increment of 10.7 mg/m3 in PM2.5 was associated with PEF changes of −2.58 L/min in 2012 and −0.55 L/min in 2013, respectively. These associations were only significant in 2012. Interleukin-8 promoter activity was significantly higher in both periods of 2012 than in 2013. There was a significant association between pulmonary function in schoolchildren and daily levels of SPM and PM2.5, but this association may differ depending on the PM’s ability to elicit interleukin-8 production. View Full-Text
Keywords: interlukin-8; peak expiratory flow; PM2.5; schoolchildren; suspended particle matter interlukin-8; peak expiratory flow; PM2.5; schoolchildren; suspended particle matter
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Watanabe, M.; Noma, H.; Kurai, J.; Sano, H.; Kitano, H.; Saito, R.; Kimura, Y.; Aiba, S.; Oshimura, M.; Shimizu, E. Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8. Int. J. Environ. Res. Public Health 2015, 12, 14229-14243.

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Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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