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Int. J. Environ. Res. Public Health 2015, 12(1), 1020-1028; doi:10.3390/ijerph120101020

Could A Deletion in Neuraminidase Stalk Strengthen Human Tropism of the Novel Avian Influenza Virus H7N9 in China, 2013?

1
Department of Sanitary Microbiology, School of Public Health, Fudan University, Shanghai 200032, China
2
Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
3
Intensive Care Unit of Burn and Trauma Center, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
4
Department of Epidemiology and Biostatistics, School of Public Health, Fudan University, Shanghai 200032, China
5
Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ontario K1H 8M5, Canada
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 25 September 2014 / Revised: 5 January 2015 / Accepted: 13 January 2015 / Published: 20 January 2015
View Full-Text   |   Download PDF [2741 KB, uploaded 20 January 2015]   |  

Abstract

Objective. A novel avian influenza A virus (AIV) H7N9 subtype which emerged in China in 2013 caused worldwide concern. Deletion of amino-acids 69 to 73 in the neuraminidase stalk was its most notable characteristic. This study is aimed to discuss the tropism and virulence effects of this deletion. Methods: Neuraminidase gene sequences of N9 subtype were collected from NCBI and GISAID. MEGA6.0, Stata12.0, and UCSF Chimera were employed for sequence aligning, significance testing, and protein tertiary structure homology modeling. Results: A total of 736 sequences were obtained; there were 81 human isolates of the novel AIV H7N9, of which 79 had the deletion. Among all the 654 avian origin sequences, only 43 had the deletion (p < 0.001). Tertiary structure displayed that the deletion obviously changed the spatial direction of neuraminidase. Conclusions: The deletion in neuraminidase stalk could have strengthened human tropism of the novel AIV H7N9, as well as its virulence. View Full-Text
Keywords: deletion; neuraminidase; H7N9; China deletion; neuraminidase; H7N9; China
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chen, L.; Zhu, F.; Xiong, C.; Zhang, Z.; Jiang, L.; Chen, Y.; Zhao, G.; Jiang, Q. Could A Deletion in Neuraminidase Stalk Strengthen Human Tropism of the Novel Avian Influenza Virus H7N9 in China, 2013? Int. J. Environ. Res. Public Health 2015, 12, 1020-1028.

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