Next Article in Journal
Relationship of Racial Composition and Cancer Risks from Air Toxics Exposure in Memphis, Tennessee, U.S.A.
Previous Article in Journal
Assessing Program Efficiency: A Time and Motion Study of the Mental Health Emergency Care — Rural Access Program in NSW Australia
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2014, 11(8), 7690-7712; doi:10.3390/ijerph110807690

Antiviral Prophylaxis and Isolation for the Control of Pandemic Influenza

School of Mathematical Sciences, University of Electronic Science and Technology of China, No. 2006, Xiyuan Avenue, West Hi-Tech Zone, Chengdu 611731, China
Author to whom correspondence should be addressed.
Received: 10 March 2014 / Revised: 22 July 2014 / Accepted: 23 July 2014 / Published: 31 July 2014
View Full-Text   |   Download PDF [354 KB, uploaded 31 July 2014]   |  


Before effective vaccines become available, antiviral drugs are considered as the major control strategies for a pandemic influenza. However, perhaps such control strategies can be severely hindered by the low-efficacy of antiviral drugs. For this reason, using antiviral drugs and an isolation strategy is included in our study. A compartmental model that allows for imported exposed individuals and asymptomatic cases is used to evaluate the effectiveness of control strategies via antiviral prophylaxis and isolation. Simulations show that isolation strategy plays a prominent role in containing transmission when antiviral drugs are not effective enough. Moreover, relatively few infected individuals need to be isolated per day. Because the accurate calculations of the needed numbers of antiviral drugs and the isolated infected are not easily available, we give two simple expressions approximating these numbers. We also derive an estimation for the total cost of these intervention strategies. These estimations obtained by a simple method provide a useful reference for the management department about the epidemic preparedness plans. View Full-Text
Keywords: mathematical modeling; pandemic influenza; antiviral prophylaxis; isolation mathematical modeling; pandemic influenza; antiviral prophylaxis; isolation

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhang, Q.; Wang, D. Antiviral Prophylaxis and Isolation for the Control of Pandemic Influenza. Int. J. Environ. Res. Public Health 2014, 11, 7690-7712.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top