Next Article in Journal
Understanding Older Adults’ Usage of Community Green Spaces in Taipei, Taiwan
Previous Article in Journal
Airborne Particulate Matter in School Classrooms of Northern Italy
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2014, 11(2), 1422-1443; doi:10.3390/ijerph110201422

Arylesterase Phenotype-Specific Positive Association Between Arylesterase Activity and Cholinesterase Specific Activity in Human Serum

1
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
2
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
3
Mercy Medical Center, Baltimore, MD 21202, USA
*
Author to whom correspondence should be addressed.
Received: 3 June 2013 / Revised: 27 December 2013 / Accepted: 15 January 2014 / Published: 27 January 2014
View Full-Text   |   Download PDF [661 KB, uploaded 19 June 2014]   |  

Abstract

Context: Cholinesterase (ChE) specific activity is the ratio of ChE activity to ChE mass and, as a biomarker of exposure to cholinesterase inhibitors, has a potential advantage over simple ChE activity. Objective: To examine the association of several potential correlates (serum arylesterase/paraoxonase activity, serum albumin, sex, age, month of blood collection, and smoking) with plasma ChE specific activity. Methods: We analyzed data from 195 cancer-free controls from a nested case-control study, accounting for potential confounding. Results: Arylesterase activity had an independent, statistically significant positive association with ChE specific activity, and its magnitude was the greatest for the arylesterase phenotype corresponding to the QQ PON1192 genotype followed by phenotypes corresponding to QR and RR genotypes. Serum albumin was positively associated with ChE specific activity. Conclusions: Plasma arylesterase activity was positively associated with plasma ChE specific activity. This observation is consistent with protection conferred by a metabolic phenotype resulting in reduced internal dose.
Keywords: pseudocholinesterase; arylesterase; paraoxonase; genetic polymorphism; biomarkers; internal dose; albumin pseudocholinesterase; arylesterase; paraoxonase; genetic polymorphism; biomarkers; internal dose; albumin
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Aoki, Y.; Helzlsouer, K.J.; Strickland, P.T. Arylesterase Phenotype-Specific Positive Association Between Arylesterase Activity and Cholinesterase Specific Activity in Human Serum. Int. J. Environ. Res. Public Health 2014, 11, 1422-1443.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top