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Int. J. Environ. Res. Public Health 2013, 10(4), 1462-1473; doi:10.3390/ijerph10041462
Article

Surveillance and Correlation of Antibiotic Consumption and Resistance of Acinetobacter baumannii complex in a Tertiary Care Hospital in Northeast China, 2003–2011

1
, 2
, 2
 and 3,*
1 Department of Laboratory Medicine, First Hospital of Jilin University, Changchun 130021, China 2 Department of Pharmacy, First Hospital of Jilin University, Changchun 130021, China 3 Department of Pediatrics, First Hospital of Jilin University, Changchun 130021, China
* Author to whom correspondence should be addressed.
Received: 6 February 2013 / Revised: 28 March 2013 / Accepted: 29 March 2013 / Published: 9 April 2013
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Abstract

This study investigated the changes in resistance of Acinetobacter baumannii complex and the association of carbapenem-resistant A. baumannii complex (CRAB) infection and hospital antimicrobial usage from 2003 to 2011 in a tertiary care hospital in northeast China. In vitro susceptibilities were determined by disk diffusion test and susceptibility profiles were determined using zone diameter interpretive criteria, as recommended by the Clinical and Laboratory Standards Institute (CLSI). Data on consumption of various antimicrobial agents, expressed as defined daily dose/1,000 patients/day, were collected retrospectively from hospital pharmacy computer database. Most of 2,485 strains of A. baumannii complex were collected from respiratory samples (1,618 isolates, 65.1%), secretions and pus (465, 18.7%) over the years. The rates of antimicrobial resistance in A. baumannii complex increased significantly over the years. The rates of CRAB were between 11.3% and 59.1% over the years. The quarterly use of anti-pseudomonal carbapenems, but not other classes of antibiotics, was strongly correlated with the increase of quarterly CRAB (β  = 1.661; p < 0.001). Dedicated use of anti-pseudomonal carbapenems would be an important intervention to control the increase of CRAB.
Keywords: Acinetobacter baumannii complex; drug resistance, microbial; antimicrobials susceptibility test; drug monitoring; antibiotic consumption Acinetobacter baumannii complex; drug resistance, microbial; antimicrobials susceptibility test; drug monitoring; antibiotic consumption
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xu, J.; Sun, Z.; Li, Y.; Zhou, Q. Surveillance and Correlation of Antibiotic Consumption and Resistance of Acinetobacter baumannii complex in a Tertiary Care Hospital in Northeast China, 2003–2011. Int. J. Environ. Res. Public Health 2013, 10, 1462-1473.

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