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Int. J. Environ. Res. Public Health 2013, 10(1), 107-143; doi:10.3390/ijerph10010107
Review

Mouse Models for Efficacy Testing of Agents against Radiation Carcinogenesis — A Literature Review

1,*  and 1,2,3
1 Department of Environmental Health Sciences, University of California, Los Angeles, 650 Charles E. Young Dr. South, CHS 71-295, Los Angeles, CA 90095, USA 2 JCCC Healthy and At-Risk Populations Program Area, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, 650 Charles E. Young Dr. South, CHS 71-295, Los Angeles, CA 90095, USA 3 Department of Radiation Oncology, University of California, Los Angeles, 650 Charles E. Young Dr. South, CHS 71-295, Los Angeles, CA 90095, USA
* Author to whom correspondence should be addressed.
Received: 6 October 2012 / Revised: 26 November 2012 / Accepted: 11 December 2012 / Published: 27 December 2012
(This article belongs to the Special Issue Radiation and Cancer Risk)
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Abstract

As the number of cancer survivors treated with radiation as a part of their therapy regimen is constantly increasing, so is concern about radiation-induced cancers. This increases the need for therapeutic and mitigating agents against secondary neoplasias. Development and efficacy testing of these agents requires not only extensive in vitro assessment, but also a set of reliable animal models of radiation-induced carcinogenesis. The laboratory mouse (Mus musculus) remains one of the best animal model systems for cancer research due to its molecular and physiological similarities to man, small size, ease of breeding in captivity and a fully sequenced genome. This work reviews relevant M. musculus inbred and F1 hybrid animal models and methodologies of induction of radiation-induced leukemia, thymic lymphoma, breast, and lung cancer in these models. Where available, the associated molecular pathologies are also included.
Keywords: radiation carcinogenesis; animal models; radiation protectors; radiation mitigators; secondary cancers radiation carcinogenesis; animal models; radiation protectors; radiation mitigators; secondary cancers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rivina, L.; Schiestl, R. Mouse Models for Efficacy Testing of Agents against Radiation Carcinogenesis — A Literature Review. Int. J. Environ. Res. Public Health 2013, 10, 107-143.

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