Recently Confirmed Apoptosis-Inducing Lead Compounds Isolated from Marine Sponge of Potential Relevance in Cancer Treatment
Abstract
:1. Introduction
‘marine sponge’ AND (programmed cell death OR apoptosis OR antitumor* OR anti-tumor* OR anticancer* OR anti-cancer* OR antineoplasm* OR anti-neoplasm*)
2. Extensively Studied Apoptotic Pathways
2.1. The Death Receptor or “Extrinsic” Apoptosis Pathway of Type I and Type II
2.2. The Mitochondrial or “Intrinsic” Apoptosis Pathway
3. Apoptosis-Inducing Lead Compounds
3.1. Alkaloids
3.1.1. Renieramycin M
3.1.2. Naamidine A
3.1.3. Psammaplysene A
3.1.4. Monanchocidin
3.1.5. Kuanoniamines A and C
3.2. Terpenoids
3.2.1. Rhabdastrellic Acid-A
3.2.2. Stellettin A and B, and Geoditin A and B
3.2.3. Jaspolide B
3.2.4. Smenospongine
3.2.5. 13E,17E-Globostellatic Acid X Methyl Ester
3.3. Lipids
3.3.1. Petrosterol-3,6-dione and 5α,6α-epoxy-Petrosterol
3.3.2. Pachastrissamine
3.3.3. Rhizochalin
3.4. Macrolides
3.4.1. Salarin C
3.4.2. Spongistatin 1
3.4.3. Candidaspongiolide
3.4.4. Irciniastatin A
4. Discussion
5. Conclusions
References
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Compound | Type | Sponge | Cell line | Reference |
---|---|---|---|---|
(1) 2,3-dihydro-2,3-dioxoaaptamine | alkaloid | Aaptos sp. | THP-1 | [26] (abstract) |
(2) 3-(methylamino)demethyl (oxy)aaptamine | alkaloid | Aaptos sp. | THP-1 | [26] (abstract) |
(3) 6-(N-morpholinyl)-4,5-dihydro-5-oxo-demethyl (oxy)aaptamine | alkaloid | Aaptos sp. | THP-1 | [26] (abstract) |
(4) kuanoniamine A | alkaloid | Oceanapia sagittaria | MCF-7 | [27] |
(5) kuanoniamine C | alkaloid | Oceanapia sagittaria | MCF-7 | [27] |
(6) Makaluvic acid C | alkaloid | Strongylodesma aliwaliensis | WHC01 WHC06 KYSE30 | [28] |
(7) Monanchocidin | alkaloid | Monanchora pulchra | THP-1 HeLa | [29] |
(8) N-1-β-d-ribofuranosyl damirone C | alkaloid | Strongylodesma aliwaliensis | WHC01 WHC06 KYSE30 | [28] |
(9) N-1-β-d-ribofuranosyl makalu-vamine I | alkaloid | Strongylodesma aliwaliensis | WHC01 WHC06 KYSE30 | [28] |
(10) N-1-β-d-ribofuranosyl makaluvic acid C | alkaloid | Strongylodesma aliwaliensis | WHC01 WHC06 KYSE30 | [28] |
(11) Naamidine A | alkaloid | Leucetta chagosensis | A-431 | [30] |
(12) Psammaplysene A | alkaloid | Psammaplysilla | Ishikawa ECC1 | [31] |
(13) Renieramycin M | alkaloid | Xestospongia sp. | NSCLC | [32] |
(14) Bastadin 6 | alkaloid | lanthella sp. | HUVEC | [33] (abstract) |
(15) (Z)-stellettic acid C | lipid | Stelletta sp. | U937 | [34] (abstract) |
(16) 5-alpha,6-alpha-epoxypetrosterol | lipid | Lanthella sp. | HL-60 | [35] |
(17) Callyspongidiol | lipid | Callyspongia sp. | HL-60 | [36] (abstract) |
(18) Jaspine B | lipid | Jaspis sp. | SK-Mel28 | [37] |
(19) Petrosterol | lipid | Lanthella sp. | HL-60 | [35] |
(20) Petrosterol-3,6-dione | lipid | Lanthella sp. | HL-60 | [35] |
(21) Rhizochalin | lipid | Rhizochalina incrustata | THP-1 HeLa SNU-C4 | [38] |
(22) Candidaspongiolide | macrolide | Candidaspongia sp. | U251 HCT116 | [39] |
(23) Irciniastatin A | macrolide | Ircinia ramose | Jurkat T | [40] |
(24) Latrunculins A and B | macrolide | Negombata magnifica | MKN45 NUGC-4 | [41] (abstract) |
(25) Salarin C | macrolide | Fascaplysinopsis sp. | K562 | [42] |
(26) Spongistatin 1 | macrolide | Spongia | Jurkat T | [43] |
(27) 13E,17E-globostellatic acid X methyl ester | terpenoid | Rhabdastrella globostellata | HUVEC | [44] |
(28) 3-epi-sodwanone K 3-acetate | terpenoid | Axinella sp. | T47D | [45] |
(29) Geoditin A | terpenoid | Geodia japonica | HL-60 HT29 | [46] [47] |
(30) Geoditin B | terpenoid | Geodia japonica | HL-60 | [46] |
(31) Heteronemin | terpenoid | Hyrtios sp. | K562 Jurkat T | [48] |
(32) Ilimaquinone | terpenoid | Hippospongia metachromia | PC3 | [49] |
(33) Jaspolide B | terpenoid | Jaspis sp. | Bel-7402 HepG2 | [50] |
(34) Rhabdastrellic acid-A | terpenoid | Rhabdastrella globostellata | HL-60 | [51] |
(35) Sipholenol A | terpenoid | Callyspongia siphonella | KB-3-1 KB-C2 KB-V1 | [52] |
(36) Smenospongine | terpenoid | Dactylospongia elegans | K56 | [53] |
(37) Sodwanone V | terpenoid | Axinella sp. | MDA-MB-231 | [45] |
(38) Stellettin A | terpenoid | Geodia japonica | HL-60 | [46] |
(39) Stellettin B | terpenoid | Geodia japonica | HL-60 | [46] |
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Essack, M.; Bajic, V.B.; Archer, J.A.C. Recently Confirmed Apoptosis-Inducing Lead Compounds Isolated from Marine Sponge of Potential Relevance in Cancer Treatment. Mar. Drugs 2011, 9, 1580-1606. https://doi.org/10.3390/md9091580
Essack M, Bajic VB, Archer JAC. Recently Confirmed Apoptosis-Inducing Lead Compounds Isolated from Marine Sponge of Potential Relevance in Cancer Treatment. Marine Drugs. 2011; 9(9):1580-1606. https://doi.org/10.3390/md9091580
Chicago/Turabian StyleEssack, Magbubah, Vladimir B. Bajic, and John A.C. Archer. 2011. "Recently Confirmed Apoptosis-Inducing Lead Compounds Isolated from Marine Sponge of Potential Relevance in Cancer Treatment" Marine Drugs 9, no. 9: 1580-1606. https://doi.org/10.3390/md9091580