Mar. Drugs 2011, 9(9), 1502-1509; doi:10.3390/md9091502
Article

A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities

Hongyu Zhang 1,2 email, Hongpeng Wang 3 email, Hongli Cui 1 email, Zonggang Li 4 email, Zeping Xie 1 email, Yang Pu 1 email, Fuchao Li 5 email and Song Qin 1,* email
1 Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China 2 Graduate University of Chinese Academy of Sciences, Beijing 100049, China 3 Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen D-37077, Germany 4 Yantai Institute of China Agricultural University, China Agricultural University, Yantai 264670, China 5 Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
* Author to whom correspondence should be addressed.
Received: 12 July 2011; in revised form: 17 August 2011 / Accepted: 19 August 2011 / Published: 9 September 2011
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Abstract: A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR (1H–1H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.
Keywords: Streptomyces; anthracene; structure establishment; cytotoxicity

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MDPI and ACS Style

Zhang, H.; Wang, H.; Cui, H.; Li, Z.; Xie, Z.; Pu, Y.; Li, F.; Qin, S. A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities. Mar. Drugs 2011, 9, 1502-1509.

AMA Style

Zhang H, Wang H, Cui H, Li Z, Xie Z, Pu Y, Li F, Qin S. A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities. Marine Drugs. 2011; 9(9):1502-1509.

Chicago/Turabian Style

Zhang, Hongyu; Wang, Hongpeng; Cui, Hongli; Li, Zonggang; Xie, Zeping; Pu, Yang; Li, Fuchao; Qin, Song. 2011. "A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities." Mar. Drugs 9, no. 9: 1502-1509.

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