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Characterization of a Novel Serine Protease Inhibitor Gene from a Marine Metagenome
Mar. Drugs 2011, 9(9), 1502-1509; doi:10.3390/md9091502

A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities

1 Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China 2 Graduate University of Chinese Academy of Sciences, Beijing 100049, China 3 Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen D-37077, Germany 4 Yantai Institute of China Agricultural University, China Agricultural University, Yantai 264670, China 5 Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
* Author to whom correspondence should be addressed.
Received: 12 July 2011 / Revised: 17 August 2011 / Accepted: 19 August 2011 / Published: 9 September 2011
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A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR (1H–1H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.
Keywords: Streptomyces; anthracene; structure establishment; cytotoxicity Streptomyces; anthracene; structure establishment; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, H.; Wang, H.; Cui, H.; Li, Z.; Xie, Z.; Pu, Y.; Li, F.; Qin, S. A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities. Mar. Drugs 2011, 9, 1502-1509.

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