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Characterization of a Novel Serine Protease Inhibitor Gene from a Marine Metagenome
Mar. Drugs 2011, 9(9), 1502-1509; doi:10.3390/md9091502
Article

A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities

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Received: 12 July 2011 / Revised: 17 August 2011 / Accepted: 19 August 2011 / Published: 9 September 2011
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Abstract

A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR (1H–1H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.
Keywords: Streptomyces; anthracene; structure establishment; cytotoxicity Streptomyces; anthracene; structure establishment; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, H.; Wang, H.; Cui, H.; Li, Z.; Xie, Z.; Pu, Y.; Li, F.; Qin, S. A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities. Mar. Drugs 2011, 9, 1502-1509.

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