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Mar. Drugs 2011, 9(9), 1502-1509; doi:10.3390/md9091502

A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities

1 Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China 2 Graduate University of Chinese Academy of Sciences, Beijing 100049, China 3 Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen D-37077, Germany 4 Yantai Institute of China Agricultural University, China Agricultural University, Yantai 264670, China 5 Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
* Author to whom correspondence should be addressed.
Received: 12 July 2011 / Revised: 17 August 2011 / Accepted: 19 August 2011 / Published: 9 September 2011
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A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR (1H–1H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.
Keywords: Streptomyces; anthracene; structure establishment; cytotoxicity Streptomyces; anthracene; structure establishment; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, H.; Wang, H.; Cui, H.; Li, Z.; Xie, Z.; Pu, Y.; Li, F.; Qin, S. A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities. Mar. Drugs 2011, 9, 1502-1509.

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