Next Article in Journal
Antioxidant and Antiproliferative Activities of Heated Sterilized Pepsin Hydrolysate Derived from Half-Fin Anchovy (Setipinna taty)
Previous Article in Journal
Functional Feed Assessment on Litopenaeus vannamei Using 100% Fish Meal Replacement by Soybean Meal, High Levels of Complex Carbohydrates and Bacillus Probiotic Strains
Mar. Drugs 2011, 9(6), 1133-1141; doi:10.3390/md9061133
Article

Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei

1
,
1
,
1
,
2
,
3
 and
1,*
Received: 23 May 2011 / Revised: 9 June 2011 / Accepted: 15 June 2011 / Published: 22 June 2011
View Full-Text   |   Download PDF [191 KB, uploaded 24 February 2015]   |   Browse Figures

Abstract

In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC50 value of 6 nM.
Keywords: marine cytotoxin; swinholide J; Theonella swinhoei marine cytotoxin; swinholide J; Theonella swinhoei
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Marino, S.D.; Festa, C.; D’Auria, M.V.; Cresteil, T.; Debitus, C.; Zampella, A. Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei. Mar. Drugs 2011, 9, 1133-1141.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert