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Mar. Drugs 2011, 9(6), 1133-1141; doi:10.3390/md9061133

Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei

1 Department of Chemistry of Natural Compounds, University of Naples, “Federico II”, via D. Montesano 49, 80131 Napoli, Italy 2 Natural Substances Institute, la Terrasse Street, 91198 Gif sur Yvette Cedex, France 3 Polynesian Research Center on Island Biodiversity, UMR 7138 CNRS, B.P. 529, 98713 Papeete, Tahiti, French Polynesia, France
* Author to whom correspondence should be addressed.
Received: 23 May 2011 / Revised: 9 June 2011 / Accepted: 15 June 2011 / Published: 22 June 2011
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In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC50 value of 6 nM.
Keywords: marine cytotoxin; swinholide J; Theonella swinhoei marine cytotoxin; swinholide J; Theonella swinhoei
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Marino, S.D.; Festa, C.; D’Auria, M.V.; Cresteil, T.; Debitus, C.; Zampella, A. Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei. Mar. Drugs 2011, 9, 1133-1141.

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