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Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei
Department of Chemistry of Natural Compounds, University of Naples, “Federico II”, via D. Montesano 49, 80131 Napoli, Italy
Natural Substances Institute, la Terrasse Street, 91198 Gif sur Yvette Cedex, France
Polynesian Research Center on Island Biodiversity, UMR 7138 CNRS, B.P. 529, 98713 Papeete, Tahiti, French Polynesia, France
* Author to whom correspondence should be addressed.
Received: 23 May 2011; in revised form: 9 June 2011 / Accepted: 15 June 2011 / Published: 22 June 2011
Abstract: In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC50 value of 6 nM.
Keywords: marine cytotoxin; swinholide J; Theonella swinhoei
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Marino, S.D.; Festa, C.; D’Auria, M.V.; Cresteil, T.; Debitus, C.; Zampella, A. Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei. Mar. Drugs 2011, 9, 1133-1141.
Marino SD, Festa C, D’Auria MV, Cresteil T, Debitus C, Zampella A. Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei. Marine Drugs. 2011; 9(6):1133-1141.
Marino, Simona De; Festa, Carmen; D’Auria, Maria Valeria; Cresteil, Thierry; Debitus, Cecile; Zampella, Angela. 2011. "Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei." Mar. Drugs 9, no. 6: 1133-1141.