Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei
AbstractIn our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC50 value of 6 nM.
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Marino, S.D.; Festa, C.; D’Auria, M.V.; Cresteil, T.; Debitus, C.; Zampella, A. Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei. Mar. Drugs 2011, 9, 1133-1141.
Marino SD, Festa C, D’Auria MV, Cresteil T, Debitus C, Zampella A. Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei. Marine Drugs. 2011; 9(6):1133-1141.Chicago/Turabian Style
Marino, Simona De; Festa, Carmen; D’Auria, Maria Valeria; Cresteil, Thierry; Debitus, Cecile; Zampella, Angela. 2011. "Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei." Mar. Drugs 9, no. 6: 1133-1141.