Mar. Drugs 2011, 9(6), 1133-1141; doi:10.3390/md9061133
Article

Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei

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Received: 23 May 2011; in revised form: 9 June 2011 / Accepted: 15 June 2011 / Published: 22 June 2011
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Abstract: In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC50 value of 6 nM.
Keywords: marine cytotoxin; swinholide J; Theonella swinhoei
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MDPI and ACS Style

Marino, S.D.; Festa, C.; D’Auria, M.V.; Cresteil, T.; Debitus, C.; Zampella, A. Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei. Mar. Drugs 2011, 9, 1133-1141.

AMA Style

Marino SD, Festa C, D’Auria MV, Cresteil T, Debitus C, Zampella A. Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei. Marine Drugs. 2011; 9(6):1133-1141.

Chicago/Turabian Style

Marino, Simona De; Festa, Carmen; D’Auria, Maria Valeria; Cresteil, Thierry; Debitus, Cecile; Zampella, Angela. 2011. "Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei." Mar. Drugs 9, no. 6: 1133-1141.


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