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Mar. Drugs 2011, 9(5), 844-851; doi:10.3390/md9050844

Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin

1
Department of Pharmacognosy, Faculty of Pharmacy, Garyounis University, P.O. Box 5341, Benghazi, Libya
2
Institute of Pharmacy, Ernst-Moritz-Arndt-University, Friedrich-Ludwig-Jahn-Strasse 17, D-17487 Greifswald, Germany
3
Friedrich-Loffler-Institute of Medical Microbiology, Ernst-Moritz-Arndt-University, Martin-Luther-Strasse 6, D-17487 Greifswald, Germany
*
Author to whom correspondence should be addressed.
Received: 19 March 2011 / Revised: 27 April 2011 / Accepted: 10 May 2011 / Published: 13 May 2011
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Abstract

A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3R,11R), (4E,8E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid (1) displayed anti-HSV-1 activity with an IC50 value of 0.45 µM.
Keywords: balticolid; antiviral; herpes simplex virus; marine fungi balticolid; antiviral; herpes simplex virus; marine fungi
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Shushni, M.A.M.; Singh, R.; Mentel, R.; Lindequist, U. Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin. Mar. Drugs 2011, 9, 844-851.

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