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Mar. Drugs 2011, 9(5), 844-851; doi:10.3390/md9050844
Article

Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin

1,* , 1
, 2
 and 3
Received: 19 March 2011; in revised form: 27 April 2011 / Accepted: 10 May 2011 / Published: 13 May 2011
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Abstract: A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3R,11R), (4E,8E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid (1) displayed anti-HSV-1 activity with an IC50 value of 0.45 µM.
Keywords: balticolid; antiviral; herpes simplex virus; marine fungi balticolid; antiviral; herpes simplex virus; marine fungi
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Shushni, M.A.M.; Singh, R.; Mentel, R.; Lindequist, U. Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin. Mar. Drugs 2011, 9, 844-851.

AMA Style

Shushni MAM, Singh R, Mentel R, Lindequist U. Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin. Marine Drugs. 2011; 9(5):844-851.

Chicago/Turabian Style

Shushni, Muftah A. M.; Singh, Rajinder; Mentel, Renate; Lindequist, Ulrike. 2011. "Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin." Mar. Drugs 9, no. 5: 844-851.



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