Next Article in Journal
Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin
Next Article in Special Issue
Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products
Previous Article in Journal
Antiproliferative Activity of Violaxanthin Isolated from Bioguided Fractionation of Dunaliella tertiolecta Extracts
Previous Article in Special Issue
Bacteriocin as Weapons in the Marine Animal-Associated Bacteria Warfare: Inventory and Potential Applications as an Aquaculture Probiotic
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2011, 9(5), 832-843; doi:10.3390/md9050832

Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea

1
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
2
School of Science and Engineering, Jinan University, Guangzhou 510632, China
3
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, China
4
School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
*
Author to whom correspondence should be addressed.
Received: 28 March 2011 / Revised: 20 April 2011 / Accepted: 4 May 2011 / Published: 12 May 2011
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
View Full-Text   |   Download PDF [332 KB, uploaded 24 February 2015]   |  

Abstract

Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 µM. View Full-Text
Keywords: endophytic fungus; Alternaria sp.; bianthraquinone; alterporriol; cytotoxicity endophytic fungus; Alternaria sp.; bianthraquinone; alterporriol; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Huang, C.-H.; Pan, J.-H.; Chen, B.; Yu, M.; Huang, H.-B.; Zhu, X.; Lu, Y.-J.; She, Z.-G.; Lin, Y.-C. Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea. Mar. Drugs 2011, 9, 832-843.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top