Mar. Drugs 2011, 9(5), 832-843; doi:10.3390/md9050832
Article

Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea

Cai-Huan Huang 1,2 email, Jia-Hui Pan 1 email, Bin Chen 1 email, Miao Yu 2 email, Hong-Bo Huang 1 email, Xun Zhu 3 email, Yong-Jun Lu 4 email, Zhi-Gang She 1,3 email and Yong-Cheng Lin 1,3,* email
1 School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China 2 School of Science and Engineering, Jinan University, Guangzhou 510632, China 3 Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, China 4 School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
* Author to whom correspondence should be addressed.
Received: 28 March 2011; in revised form: 20 April 2011 / Accepted: 4 May 2011 / Published: 12 May 2011
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
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Abstract: Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 µM.
Keywords: endophytic fungus; Alternaria sp.; bianthraquinone; alterporriol; cytotoxicity

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Cite This Article

MDPI and ACS Style

Huang, C.-H.; Pan, J.-H.; Chen, B.; Yu, M.; Huang, H.-B.; Zhu, X.; Lu, Y.-J.; She, Z.-G.; Lin, Y.-C. Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea. Mar. Drugs 2011, 9, 832-843.

AMA Style

Huang C-H, Pan J-H, Chen B, Yu M, Huang H-B, Zhu X, Lu Y-J, She Z-G, Lin Y-C. Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea. Marine Drugs. 2011; 9(5):832-843.

Chicago/Turabian Style

Huang, Cai-Huan; Pan, Jia-Hui; Chen, Bin; Yu, Miao; Huang, Hong-Bo; Zhu, Xun; Lu, Yong-Jun; She, Zhi-Gang; Lin, Yong-Cheng. 2011. "Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea." Mar. Drugs 9, no. 5: 832-843.

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