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Mar. Drugs 2011, 9(5), 832-843; doi:10.3390/md9050832
Article

Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea

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1 School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China 2 School of Science and Engineering, Jinan University, Guangzhou 510632, China 3 Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education of Guangdong, Guangzhou 510080, China 4 School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
* Author to whom correspondence should be addressed.
Received: 28 March 2011 / Revised: 20 April 2011 / Accepted: 4 May 2011 / Published: 12 May 2011
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
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Abstract

Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 µM.
Keywords: endophytic fungus; Alternaria sp.; bianthraquinone; alterporriol; cytotoxicity endophytic fungus; Alternaria sp.; bianthraquinone; alterporriol; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Huang, C.-H.; Pan, J.-H.; Chen, B.; Yu, M.; Huang, H.-B.; Zhu, X.; Lu, Y.-J.; She, Z.-G.; Lin, Y.-C. Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea. Mar. Drugs 2011, 9, 832-843.

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