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Mar. Drugs 2011, 9(5), 832-843; doi:10.3390/md9050832
Article

Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea

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Received: 28 March 2011; in revised form: 20 April 2011 / Accepted: 4 May 2011 / Published: 12 May 2011
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
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Abstract: Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2–C-2′ linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC50 values ranging from 13.1 to 29.1 µM.
Keywords: endophytic fungus; Alternaria sp.; bianthraquinone; alterporriol; cytotoxicity endophytic fungus; Alternaria sp.; bianthraquinone; alterporriol; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, C.-H.; Pan, J.-H.; Chen, B.; Yu, M.; Huang, H.-B.; Zhu, X.; Lu, Y.-J.; She, Z.-G.; Lin, Y.-C. Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea. Mar. Drugs 2011, 9, 832-843.

AMA Style

Huang C-H, Pan J-H, Chen B, Yu M, Huang H-B, Zhu X, Lu Y-J, She Z-G, Lin Y-C. Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea. Marine Drugs. 2011; 9(5):832-843.

Chicago/Turabian Style

Huang, Cai-Huan; Pan, Jia-Hui; Chen, Bin; Yu, Miao; Huang, Hong-Bo; Zhu, Xun; Lu, Yong-Jun; She, Zhi-Gang; Lin, Yong-Cheng. 2011. "Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea." Mar. Drugs 9, no. 5: 832-843.



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