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Mar. Drugs 2011, 9(3), 369-381; doi:10.3390/md9030369
Article

Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites

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Department of Chemistry & Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI, Canada These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 4 February 2011 / Revised: 6 March 2011 / Accepted: 18 March 2011 / Published: 21 March 2011
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Abstract

Marine invertebrates have proven to be a rich source of secondary metabolites. The growing recognition that marine microorganisms associated with invertebrate hosts are involved in the biosynthesis of secondary metabolites offers new alternatives for the discovery and development of marine natural products. However, the discovery of microorganisms producing secondary metabolites previously attributed to an invertebrate host poses a significant challenge. This study describes an efficient chemical screening method utilizing a 96-well plate-based bacterial cultivation strategy to identify and isolate microbial producers of marine invertebrate-associated metabolites.
Keywords: chemical screening; coral-associated bacteria; UPLC/MS; gorgonian coral chemical screening; coral-associated bacteria; UPLC/MS; gorgonian coral
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Berrue, F.; Withers, S.T.; Haltli, B.; Withers, J.; Kerr, R.G. Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites. Mar. Drugs 2011, 9, 369-381.

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