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Mar. Drugs 2011, 9(11), 2316-2368; doi:10.3390/md9112316

Brominated Compounds from Marine Sponges of the Genus Aplysina and a Compilation of Their 13C NMR Spectral Data

Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil
Department of Pharmacy, State University of Paraiba, Campina Grande 58100-000, PB, Brazil
Authors to whom correspondence should be addressed.
Received: 18 August 2011 / Revised: 24 October 2011 / Accepted: 31 October 2011 / Published: 10 November 2011


Aplysina is the best representative genus of the family Aplysinidae. Halogenated substances are its main class of metabolites. These substances contribute greatly to the chemotaxonomy and characterization of the sponges belonging to this genus. Due to their pharmacological activities, these alkaloids are of special interest. The chemistry of halogenated substances and of the alkaloids has long been extensively studied in terrestrial organisms, while the number of marine organisms studied has just started to increase in the last decades. This review describes 101 halogenated substances from 14 species of Aplysina from different parts of the world. These substances can be divided into the following classes: bromotyramines (A), cavernicolins (B), hydroverongiaquinols (C), bromotyrosineketals (D), bromotyrosine lactone derivatives (E), oxazolidones (F), spiroisoxazolines (G), verongiabenzenoids (H), verongiaquinols (I), and dibromocyclohexadienes (J). A compilation of their 13C NMR data is also part of the review. For this purpose 138 references were consulted. View Full-Text
Keywords: Aplysina; marine sponges; halogenated substances; 13C NMR; review Aplysina; marine sponges; halogenated substances; 13C NMR; review

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lira, N.S.; Montes, R.C.; Tavares, J.F.; Silva, M.S.; Cunha, E.V.L.; Athayde-Filho, P.F.; Rodrigues, L.C.; Dias, C.S.; Barbosa-Filho, J.M. Brominated Compounds from Marine Sponges of the Genus Aplysina and a Compilation of Their 13C NMR Spectral Data. Mar. Drugs 2011, 9, 2316-2368.

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