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Mar. Drugs 2011, 9(10), 2036-2045; doi:10.3390/md9102036
Article

Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

1
,
2,3
,
4,5
,
1
,
6
 and
1,7,*
These authors contributed equally to the work. 1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 3 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan 5 Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan 6 Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan 7 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 31 August 2011 / Revised: 28 September 2011 / Accepted: 12 October 2011 / Published: 19 October 2011
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Abstract

Four new eunicellin-based diterpenoids, krempfielins A–D (14), along with two known compounds (5 and 6) have been isolated from a soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 5 and 6 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 2, 3, 5 and 6 were shown to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells.
Keywords: soft coral; Cladiella krempfi; eunicellin-based diterpenoids; krempfielins; cytotoxic activity; anti-inflammatory activity soft coral; Cladiella krempfi; eunicellin-based diterpenoids; krempfielins; cytotoxic activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Tai, C.-J.; Su, J.-H.; Huang, M.-S.; Wen, Z.-H.; Dai, C.-F.; Sheu, J.-H. Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi. Mar. Drugs 2011, 9, 2036-2045.

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