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Mar. Drugs 2011, 9(10), 2036-2045; doi:10.3390/md9102036
Article

Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

1
,
2,3
,
4,5
,
1
,
6
 and
1,7,*
Received: 31 August 2011 / Revised: 28 September 2011 / Accepted: 12 October 2011 / Published: 19 October 2011
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Abstract

Four new eunicellin-based diterpenoids, krempfielins A–D (14), along with two known compounds (5 and 6) have been isolated from a soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 5 and 6 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 2, 3, 5 and 6 were shown to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells.
Keywords: soft coral; Cladiella krempfi; eunicellin-based diterpenoids; krempfielins; cytotoxic activity; anti-inflammatory activity soft coral; Cladiella krempfi; eunicellin-based diterpenoids; krempfielins; cytotoxic activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tai, C.-J.; Su, J.-H.; Huang, M.-S.; Wen, Z.-H.; Dai, C.-F.; Sheu, J.-H. Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi. Mar. Drugs 2011, 9, 2036-2045.

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