Mar. Drugs 2011, 9(10), 1955-1968; doi:10.3390/md9101955
Article

Bioactive Cembranoids from the Soft Coral Sinularia crassa

1,2email, 1email, 1email, 1,3email, 1,3email, 4email, 5email and 1,3,* email
Received: 18 August 2011; in revised form: 26 September 2011 / Accepted: 9 October 2011 / Published: 17 October 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Eight new cembranoids, crassarines A–H (18) were isolated from the Formosan soft coral Sinularia crassa. Compounds 13 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute configuration of 6 was determined using the Mosher’s method. Compounds 6 and 8 were found to significantly inhibit the expression of both pro-inflammatory iNOS and COX-2 proteins at 10 µM, respectively, while compounds 48 were found to be non-cytotoxic toward the selected human liver cancer cells.
Keywords: Sinularia crassa; crassarines A–H; anti-inflammatory
PDF Full-text Download PDF Full-Text [739 KB, Updated Version, uploaded 18 October 2011 14:05 CEST]
The original version is still available [725 KB, uploaded 17 October 2011 15:52 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Chao, C.-H.; Chou, K.-J.; Huang, C.-Y.; Wen, Z.-H.; Hsu, C.-H.; Wu, Y.-C.; Dai, C.-F.; Sheu, J.-H. Bioactive Cembranoids from the Soft Coral Sinularia crassa. Mar. Drugs 2011, 9, 1955-1968.

AMA Style

Chao C-H, Chou K-J, Huang C-Y, Wen Z-H, Hsu C-H, Wu Y-C, Dai C-F, Sheu J-H. Bioactive Cembranoids from the Soft Coral Sinularia crassa. Marine Drugs. 2011; 9(10):1955-1968.

Chicago/Turabian Style

Chao, Chih-Hua; Chou, Kuei-Ju; Huang, Chiung-Yao; Wen, Zhi-Hong; Hsu, Chi-Hsin; Wu, Yang-Chang; Dai, Chang-Feng; Sheu, Jyh-Horng. 2011. "Bioactive Cembranoids from the Soft Coral Sinularia crassa." Mar. Drugs 9, no. 10: 1955-1968.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert