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Mar. Drugs 2011, 9(10), 1955-1968; doi:10.3390/md9101955
Article

Bioactive Cembranoids from the Soft Coral Sinularia crassa

1,2
, 1
, 1
, 1,3
, 1,3
, 4
, 5
 and 1,3,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Chinese Medicinal Research and Development Center, China Medical University and Hospital, Taichung 404, Taiwan 3 Asian Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 4 College of Chinese Medicine, China Medical University, Taichung 404, Taiwan 5 Institute of Oceanography, National Taiwan University, Taipei, Taiwan
* Author to whom correspondence should be addressed.
Received: 18 August 2011 / Revised: 26 September 2011 / Accepted: 9 October 2011 / Published: 17 October 2011
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Abstract

Eight new cembranoids, crassarines A–H (18) were isolated from the Formosan soft coral Sinularia crassa. Compounds 13 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute configuration of 6 was determined using the Mosher’s method. Compounds 6 and 8 were found to significantly inhibit the expression of both pro-inflammatory iNOS and COX-2 proteins at 10 µM, respectively, while compounds 48 were found to be non-cytotoxic toward the selected human liver cancer cells.
Keywords: Sinularia crassa; crassarines A–H; anti-inflammatory Sinularia crassa; crassarines A–H; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chao, C.-H.; Chou, K.-J.; Huang, C.-Y.; Wen, Z.-H.; Hsu, C.-H.; Wu, Y.-C.; Dai, C.-F.; Sheu, J.-H. Bioactive Cembranoids from the Soft Coral Sinularia crassa. Mar. Drugs 2011, 9, 1955-1968.

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