Bioactive Cembranoids from the Soft Coral Sinularia crassa
AbstractEight new cembranoids, crassarines A–H (1–8) were isolated from the Formosan soft coral Sinularia crassa. Compounds 1–3 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute configuration of 6 was determined using the Mosher’s method. Compounds 6 and 8 were found to significantly inhibit the expression of both pro-inflammatory iNOS and COX-2 proteins at 10 µM, respectively, while compounds 4–8 were found to be non-cytotoxic toward the selected human liver cancer cells.
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Chao, C.-H.; Chou, K.-J.; Huang, C.-Y.; Wen, Z.-H.; Hsu, C.-H.; Wu, Y.-C.; Dai, C.-F.; Sheu, J.-H. Bioactive Cembranoids from the Soft Coral Sinularia crassa. Mar. Drugs 2011, 9, 1955-1968.
Chao C-H, Chou K-J, Huang C-Y, Wen Z-H, Hsu C-H, Wu Y-C, Dai C-F, Sheu J-H. Bioactive Cembranoids from the Soft Coral Sinularia crassa. Marine Drugs. 2011; 9(10):1955-1968.Chicago/Turabian Style
Chao, Chih-Hua; Chou, Kuei-Ju; Huang, Chiung-Yao; Wen, Zhi-Hong; Hsu, Chi-Hsin; Wu, Yang-Chang; Dai, Chang-Feng; Sheu, Jyh-Horng. 2011. "Bioactive Cembranoids from the Soft Coral Sinularia crassa." Mar. Drugs 9, no. 10: 1955-1968.