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Mar. Drugs 2011, 9(10), 1955-1968; doi:10.3390/md9101955
Article

Bioactive Cembranoids from the Soft Coral Sinularia crassa

1,2
, 1
, 1
, 1,3
, 1,3
, 4
, 5
 and 1,3,*
Received: 18 August 2011; in revised form: 26 September 2011 / Accepted: 9 October 2011 / Published: 17 October 2011
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Abstract: Eight new cembranoids, crassarines A–H (18) were isolated from the Formosan soft coral Sinularia crassa. Compounds 13 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute configuration of 6 was determined using the Mosher’s method. Compounds 6 and 8 were found to significantly inhibit the expression of both pro-inflammatory iNOS and COX-2 proteins at 10 µM, respectively, while compounds 48 were found to be non-cytotoxic toward the selected human liver cancer cells.
Keywords: Sinularia crassa; crassarines A–H; anti-inflammatory Sinularia crassa; crassarines A–H; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chao, C.-H.; Chou, K.-J.; Huang, C.-Y.; Wen, Z.-H.; Hsu, C.-H.; Wu, Y.-C.; Dai, C.-F.; Sheu, J.-H. Bioactive Cembranoids from the Soft Coral Sinularia crassa. Mar. Drugs 2011, 9, 1955-1968.

AMA Style

Chao C-H, Chou K-J, Huang C-Y, Wen Z-H, Hsu C-H, Wu Y-C, Dai C-F, Sheu J-H. Bioactive Cembranoids from the Soft Coral Sinularia crassa. Marine Drugs. 2011; 9(10):1955-1968.

Chicago/Turabian Style

Chao, Chih-Hua; Chou, Kuei-Ju; Huang, Chiung-Yao; Wen, Zhi-Hong; Hsu, Chi-Hsin; Wu, Yang-Chang; Dai, Chang-Feng; Sheu, Jyh-Horng. 2011. "Bioactive Cembranoids from the Soft Coral Sinularia crassa." Mar. Drugs 9, no. 10: 1955-1968.



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