Next Article in Journal
The Structural Diversity of Carbohydrate Antigens of Selected Gram-Negative Marine Bacteria
Previous Article in Journal
Studies on Synthesis and Structure-Activity Relationship (SAR) of Derivatives of a New Natural Product from Marine Fungi as Inhibitors of Influenza Virus Neuraminidase
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2011, 9(10), 1902-1913; doi:10.3390/md9101902

Antiparasitic Bromotyrosine Derivatives from the Marine Sponge Verongula rigida

1
Marine Natural Products Research Group, Pharmaceutical Chemistry Faculty, University of Antioquia, Medellin AA 1226, Colombia
2
Chemical Institute of Nice, UMR 6001 CNRS, University of Nice—Sophia Antipolis, Parc Valrose, 06108, Nice Cedex 02, France
3
Program for the Study and Control of Tropical Diseases (PECET), University of Antioquia, Medellin AA 1226, Colombia
*
Author to whom correspondence should be addressed.
Received: 6 September 2011 / Revised: 21 September 2011 / Accepted: 30 September 2011 / Published: 14 October 2011
View Full-Text   |   Download PDF [218 KB, uploaded 24 February 2015]   |  

Abstract

Nine bromotyrosine-derived compounds were isolated from the Caribbean marine sponge Verongula rigida. Two of them, aeroplysinin-1 (1) and dihydroxyaerothionin (2), are known compounds for this species, and the other seven are unknown compounds for this species, namely: 3,5-dibromo-N,N,N-trimethyltyraminium (3), 3,5-dibromo-N,N,N, O-tetramethyltyraminium (4), purealidin R (5), 19-deoxyfistularin 3 (6), purealidin B (7), 11-hydroxyaerothionin (8) and fistularin-3 (9). Structural determination of the isolated compounds was performed using one- and two-dimensional NMR, MS and other spectroscopy data. All isolated compounds were screened for their in vitro activity against three parasitic protozoa: Leishmania panamensis, Plasmodium falciparum and Trypanosoma cruzi. Compounds 7 and 8 showed selective antiparasitic activity at 10 and 5 µM against Leishmania and Plasmodium parasites, respectively. Cytotoxicity of these compounds on a human promonocytic cell line was also assessed. View Full-Text
Keywords: bromotyrosines; Verongula rigida; antiplasmodial activity; leishmanicidal activity; trypanocidal activity bromotyrosines; Verongula rigida; antiplasmodial activity; leishmanicidal activity; trypanocidal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Galeano, E.; Thomas, O.P.; Robledo, S.; Munoz, D.; Martinez, A. Antiparasitic Bromotyrosine Derivatives from the Marine Sponge Verongula rigida. Mar. Drugs 2011, 9, 1902-1913.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top