Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs
Abstract
:1. Introduction
2. Results and Discussion
2.1. Elevations in intraoocytic cAMP trigger GVBD in nemerteans as opposed to generally inhibiting GVBD in mammals
2.2. ERK 1/2 MAPKs are activated before, but not required for, GVBD in nemerteans
2.3. Src-family kinase activation does not appear to be needed for GVBD in nemerteans
2.5. Stimulators of AMP-activated kinase block SW- but not cAMP-induced GVBD in nemerteans
2.6. Egg maturation in nemerteans requires activation of pre-MPF following stimulation by either SW or cAMP elevators
3. Conclusions
4. Experimental
Acknowledgments
References
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Signal regulating egg maturation: | Positive (+) or negative (−) effect of signal on GVBD | |
---|---|---|
in nemerteans [refs] (notes): | in mammals [refs] (notes): | |
Intraoocytic cAMP elevation | + [16,35,36,43] | − [17–27] |
ERK 1/2 MAPK activation | + [41–44] (a) | + [14,45–48] (a,b) |
Src family kinase activation | − [50] | − [51] or + [52] |
Protein kinase C activation | + [36,44] [c] | − [60–66] (d) |
Intraoocytic AMP kinase activation | − [74] | + [75–77] (e) |
Increased Cdc2 kinase activity via conversion of pre-MPF into MPF | + [43] | + [4,14] |
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Stricker, S.A.; Escalona, J.R.; Abernathy, S.; Marquardt, A. Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs. Mar. Drugs 2010, 8, 2417-2434. https://doi.org/10.3390/md8082417
Stricker SA, Escalona JR, Abernathy S, Marquardt A. Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs. Marine Drugs. 2010; 8(8):2417-2434. https://doi.org/10.3390/md8082417
Chicago/Turabian StyleStricker, Stephen A., Jose R. Escalona, Samuel Abernathy, and Alicia Marquardt. 2010. "Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs" Marine Drugs 8, no. 8: 2417-2434. https://doi.org/10.3390/md8082417