Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)

doi:10.3390/md8072014

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Mar. Drugs 2010, 8(7), 2014-2020; doi:10.3390/md8072014

Article

Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)

Chih-Yang Liu ^1,2 , Tsong-Long Hwang ³ , Mei-Ru Lin ² , Yung-Husan Chen ² , Yu-Chia Chang ^1,2 , Lee-Shing Fang ⁴ , Wei-Hsien Wang ^2,5 , Yang-Chang Wu ⁶^,* and Ping-Jyun Sung ^1,2,5^,*

¹ Department of Life Science and Graduate Institute of Biotechnology, Graduate Institute of Marine Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan ² National Museum of Marine Biology and Aquarium, Checheng, Pingtung 944, Taiwan ³ Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan ⁴ Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan ⁵ Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan ⁶ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan

* Authors to whom correspondence should be addressed.

Received: 12 May 2010; in revised form: 8 June 2010 / Accepted: 28 June 2010 / Published: 29 June 2010

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Abstract: A new bioactive sterol glycoside, 3β-O-(3\',4\'-di-O-acetyl-β-D-arabinopyranosyl)-25ξ-cholestane-3β,5α,6β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.

Keywords: Carijoa; carijoside; glycoside; superoxide anion; elastase; cytotoxicity

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Cite This Article

MDPI and ACS Style

Liu, C.-Y.; Hwang, T.-L.; Lin, M.-R.; Chen, Y.-H.; Chang, Y.-C.; Fang, L.-S.; Wang, W.-H.; Wu, Y.-C.; Sung, P.-J. Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae). Mar. Drugs 2010, 8, 2014-2020.

AMA Style

Liu C.-Y., Hwang T.-L., Lin M.-R., Chen Y.-H., Chang Y.-C., Fang L.-S., Wang W.-H., Wu Y.-C., Sung P.-J. Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae). Marine Drugs. 2010; 8(7):2014-2020.

Chicago/Turabian Style

Liu, Chih-Yang; Hwang, Tsong-Long; Lin, Mei-Ru; Chen, Yung-Husan; Chang, Yu-Chia; Fang, Lee-Shing; Wang, Wei-Hsien; Wu, Yang-Chang; Sung, Ping-Jyun. 2010. "Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)." Mar. Drugs 8, no. 7: 2014-2020.

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