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Mar. Drugs 2010, 8(7), 2014-2020; doi:10.3390/md8072014
Article

Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)

1,2
, 3
, 2
, 2
, 1,2
, 4
, 2,5
, 6,*  and 1,2,5,*
1 Department of Life Science and Graduate Institute of Biotechnology, Graduate Institute of Marine Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan 2 National Museum of Marine Biology and Aquarium, Checheng, Pingtung 944, Taiwan 3 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 4 Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan 5 Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 6 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
* Authors to whom correspondence should be addressed.
Received: 12 May 2010 / Revised: 8 June 2010 / Accepted: 28 June 2010 / Published: 29 June 2010
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Abstract

A new bioactive sterol glycoside, 3β-O-(3',4'-di-O-acetyl-β-D-arabinopyranosyl)-25ξ-cholestane-3β,5α,6β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells.
Keywords: Carijoa; carijoside; glycoside; superoxide anion; elastase; cytotoxicity Carijoa; carijoside; glycoside; superoxide anion; elastase; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liu, C.-Y.; Hwang, T.-L.; Lin, M.-R.; Chen, Y.-H.; Chang, Y.-C.; Fang, L.-S.; Wang, W.-H.; Wu, Y.-C.; Sung, P.-J. Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae). Mar. Drugs 2010, 8, 2014-2020.

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