Next Article in Journal
Palytoxin and Analogs: Biological and Ecological Effects
Previous Article in Journal
Correction: Banack, S.A. et al. Production of the Neurotoxin BMAA by a Marine Cyanobacterium. Mar. Drugs 2007, 5, 180–196
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2010, 8(7), 2014-2020; https://doi.org/10.3390/md8072014

Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae)

1
Department of Life Science and Graduate Institute of Biotechnology, Graduate Institute of Marine Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan
2
National Museum of Marine Biology and Aquarium, Checheng, Pingtung 944, Taiwan
3
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
4
Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
5
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
6
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 12 May 2010 / Revised: 8 June 2010 / Accepted: 28 June 2010 / Published: 29 June 2010
View Full-Text   |   Download PDF [140 KB, uploaded 24 February 2015]   |  

Abstract

A new bioactive sterol glycoside, 3β-O-(3',4'-di-O-acetyl-β-D-arabinopyranosyl)-25ξ-cholestane-3β,5α,6β,26-tetrol-26-acetate) (carijoside A, 1), was isolated from an octocoral identified as Carijoa sp. The structure of glycoside 1 was established by spectroscopic methods and by comparison with spectral data for the other known glycosides. Carijoside A (1) displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils and this compound exhibited moderate cytotoxicity toward DLD-1, P388D1, HL-60, and CCRF-CEM tumor cells. View Full-Text
Keywords: Carijoa; carijoside; glycoside; superoxide anion; elastase; cytotoxicity Carijoa; carijoside; glycoside; superoxide anion; elastase; cytotoxicity
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Liu, C.-Y.; Hwang, T.-L.; Lin, M.-R.; Chen, Y.-H.; Chang, Y.-C.; Fang, L.-S.; Wang, W.-H.; Wu, Y.-C.; Sung, P.-J. Carijoside A, a Bioactive Sterol Glycoside from an Octocoral Carijoa sp. (Clavulariidae). Mar. Drugs 2010, 8, 2014-2020.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top