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Anti-photoaging and Photoprotective Compounds Derived from Marine Organisms
Department of Chemistry, Pukyong National University, Busan 608-737, Korea
Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Korea
* Author to whom correspondence should be addressed.
Received: 22 February 2010; in revised form: 30 March 2010 / Accepted: 7 April 2010 / Published: 8 April 2010
Abstract: Marine organisms form a prominent component of the oceanic population, which significantly contribute in the production of cosmeceutical and pharmaceutical molecules with biologically efficient moieties. In addition to the molecules of various biological activities like anti-bacterial, anti-cancerous, anti-inflammatory and anti-oxidative etc., these organisms also produce potential photoprotective or anti-photoaging agents, which are attracting present day researchers. Continuous exposure to UV irradiation (both UV-A and UV-B) leads to the skin cancer and other photoaging complications, which are typically mediated by the reactive oxygen species (ROS), generated in the oxidative pathways. Many of the anti-oxidative and anti-photoaging compounds have been identified previously, which work efficiently against photodamage of the skin. Recently, marine originated photoprotective or anti-photoaging behavior was observed in the methanol extracts of Corallina pilulifera (CPM). These extracts were found to exert potent antioxidant activity and protective effect on UV-A-induced oxidative stress in human dermal fibroblast (HDF) cells by protecting DNA and also by inhibiting matrix metalloproteinases (MMPs), a key component in photoaging of the skin due to exposure to UV-A. The present review depicts various other photoprotective compounds from algae and other marine sources for further elaborative research and their probable use in cosmeceutical and pharmaceutical industries.
Keywords: anti-photoaging; photoprotection; UV irradiation; reactive oxygen species (ROS); matrix metalloproteinases (MMPs)
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MDPI and ACS Style
Pallela, R.; Na-Young, Y.; Kim, S.-K. Anti-photoaging and Photoprotective Compounds Derived from Marine Organisms. Mar. Drugs 2010, 8, 1189-1202.
Pallela R, Na-Young Y, Kim S-K. Anti-photoaging and Photoprotective Compounds Derived from Marine Organisms. Marine Drugs. 2010; 8(4):1189-1202.
Pallela, Ramjee; Na-Young, Yoon; Kim, Se-Kwon. 2010. "Anti-photoaging and Photoprotective Compounds Derived from Marine Organisms." Mar. Drugs 8, no. 4: 1189-1202.