Mar. Drugs 2010, 8(3), 413-428; doi:10.3390/md8030413
Article

Seasonal Variations of the Activity of Antioxidant Defense Enzymes in the Red Mullet (Mullus barbatus l.) from the Adriatic Sea

Department of Physiology, Institute for Biological Research "Siniša Stanković", University of Belgrade, 11060 Belgrade, Serbia
* Author to whom correspondence should be addressed.
Received: 28 December 2009; in revised form: 1 February 2010 / Accepted: 5 February 2010 / Published: 26 February 2010
(This article belongs to the Special Issue Enzymes from the Sea: Sources, Molecular Biology and Bioprocesses)
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Abstract: This study investigated seasonal variations of antioxidant defense enzyme activities: total, manganese, copper zinc containing superoxide dismutase (Tot SOD, Mn SOD, CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST) activity in the liver and white muscle of red mullet (Mullus barbatus). The investigations were performed in winter and spring at two localities: Near Bar (NB) and Estuary of the River Bojana (EB) in the Southern Adriatic Sea. At both sites, Mn SOD, GSH-Px, GR and GST activities decreased in the liver in spring. In the white muscle, activities of Mn SOD, GSH-Px, GR and GST in NB decreased in spring. GR decreased in spring in EB, while CAT activity was higher in spring at both sites. The results of Principal Component Analysis (PCA) based on correlations indicated a clear separation of various sampling periods for both investigated tissues and a marked difference between two seasons. Our study is the first report on antioxidant defense enzyme activities in the red mullet in the Southern Adriatic Sea. It indicates that seasonal variations of antioxidant defense enzyme activities should be used in further biomonitoring studies in fish species.
Keywords: red mullet; oxidative stress; liver; white muscle; Adriatic Sea

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MDPI and ACS Style

Pavlović, S.Z.; Mitić, S.S.B.; Radovanović, T.B.; Perendija, B.R.; Despotović, S.G.; Gavrić, J.P.; Saičić, Z.S. Seasonal Variations of the Activity of Antioxidant Defense Enzymes in the Red Mullet (Mullus barbatus l.) from the Adriatic Sea. Mar. Drugs 2010, 8, 413-428.

AMA Style

Pavlović SZ, Mitić SSB, Radovanović TB, Perendija BR, Despotović SG, Gavrić JP, Saičić ZS. Seasonal Variations of the Activity of Antioxidant Defense Enzymes in the Red Mullet (Mullus barbatus l.) from the Adriatic Sea. Marine Drugs. 2010; 8(3):413-428.

Chicago/Turabian Style

Pavlović, Sladjan Z.; Mitić, Slavica S. Borković; Radovanović, Tijana B.; Perendija, Branka R.; Despotović, Svetlana G.; Gavrić, Jelena P.; Saičić, Zorica S. 2010. "Seasonal Variations of the Activity of Antioxidant Defense Enzymes in the Red Mullet (Mullus barbatus l.) from the Adriatic Sea." Mar. Drugs 8, no. 3: 413-428.

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