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Mar. Drugs 2010, 8(12), 2936-2945; doi:10.3390/md8122936

Article

Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp.

Yung-Husan Chen ¹ , Chia-Ying Tai ^1,2 , Tsong-Long Hwang ³ , Ching-Feng Weng ⁴ , Jan-Jung Li ¹ , Lee-Shing Fang ⁵ , Wei-Hsien Wang ^1,6,7 , Yang-Chang Wu ^8,9,*  and Ping-Jyun Sung ^1,2,4,6,7,*

¹ National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan ² Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan ³ Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan ⁴ Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan ⁵ Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan ⁶ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan ⁷ Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan ⁸ Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan ⁹ Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan

* Authors to whom correspondence should be addressed.

Received: 29 October 2010; in revised form: 25 November 2010 / Accepted: 1 December 2010 / Published: 6 December 2010

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Abstract: Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.

Keywords: cladielloide; eunicellin; octocoral; cytotoxicity; superoxide anion; elastase

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