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Mar. Drugs 2010, 8(12), 2936-2945; doi:10.3390/md8122936

Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp.

1
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
2
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
3
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
4
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan
5
Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
6
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
7
Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
8
Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
9
Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 29 October 2010 / Revised: 25 November 2010 / Accepted: 1 December 2010 / Published: 6 December 2010
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Abstract

Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils. View Full-Text
Keywords: cladielloide; eunicellin; octocoral; cytotoxicity; superoxide anion; elastase cladielloide; eunicellin; octocoral; cytotoxicity; superoxide anion; elastase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chen, Y.-H.; Tai, C.-Y.; Hwang, T.-L.; Weng, C.-F.; Li, J.-J.; Fang, L.-S.; Wang, W.-H.; Wu, Y.-C.; Sung, P.-J. Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp.. Mar. Drugs 2010, 8, 2936-2945.

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