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Mar. Drugs 2010, 8(12), 2936-2945; doi:10.3390/md8122936
Article

Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp.

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8,9,*  and 1,2,4,6,7,*
1 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 2 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 3 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 4 Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan 5 Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan 6 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 7 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 8 Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan 9 Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 29 October 2010 / Revised: 25 November 2010 / Accepted: 1 December 2010 / Published: 6 December 2010
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Abstract

Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.
Keywords: cladielloide; eunicellin; octocoral; cytotoxicity; superoxide anion; elastase cladielloide; eunicellin; octocoral; cytotoxicity; superoxide anion; elastase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, Y.-H.; Tai, C.-Y.; Hwang, T.-L.; Weng, C.-F.; Li, J.-J.; Fang, L.-S.; Wang, W.-H.; Wu, Y.-C.; Sung, P.-J. Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp.. Mar. Drugs 2010, 8, 2936-2945.

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