Next Article in Journal
Antibacterial Compounds from Marine Vibrionaceae Isolated on a Global Expedition
Previous Article in Journal
Bioactive Dehydrotyrosyl and Dehydrodopyl Compounds of Marine Origin
Mar. Drugs 2010, 8(12), 2936-2945; doi:10.3390/md8122936
Article

Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp.

1
,
1,2
,
3
,
4
,
1
,
5
,
1,6,7
,
8,9,*  and 1,2,4,6,7,*
1 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 2 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 3 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 4 Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan 5 Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan 6 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 7 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 8 Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan 9 Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 29 October 2010 / Revised: 25 November 2010 / Accepted: 1 December 2010 / Published: 6 December 2010
View Full-Text   |   Download PDF [233 KB, uploaded 24 February 2015]   |  

Abstract

Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.
Keywords: cladielloide; eunicellin; octocoral; cytotoxicity; superoxide anion; elastase cladielloide; eunicellin; octocoral; cytotoxicity; superoxide anion; elastase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Chen, Y.-H.; Tai, C.-Y.; Hwang, T.-L.; Weng, C.-F.; Li, J.-J.; Fang, L.-S.; Wang, W.-H.; Wu, Y.-C.; Sung, P.-J. Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp.. Mar. Drugs 2010, 8, 2936-2945.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert