Next Article in Journal
Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp.
Next Article in Special Issue
Search for Hydrophilic Marine Fungal Metabolites: A Rational Approach for Their Production and Extraction in a Bioactivity Screening Context
Previous Article in Journal
Screening and cDNA Cloning of Kv1 Potassium Channel Toxins in Sea Anemones
Previous Article in Special Issue
Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum
Mar. Drugs 2010, 8(12), 2906-2935; doi:10.3390/md8122906

Bioactive Dehydrotyrosyl and Dehydrodopyl Compounds of Marine Origin

1,*  and 2
Received: 19 October 2010 / Revised: 26 November 2010 / Accepted: 1 December 2010 / Published: 6 December 2010
Abstract: The amino acid, tyrosine, and its hydroxylated product, 3,4-dihydroxyphenylalanine (dopa), plays an important role in the biogenesis of a number of potentially important bioactive molecules in marine organisms. Interestingly, several of these tyrosyl and dopa‑containing compounds possess dehydro groups in their side chains. Examples span the range from simple dehydrotyrosine and dehydrodopamines to complex metabolic products, including peptides and polycyclic alkaloids. Based on structural information, these compounds can be subdivided into five categories: (a) Simple dehydrotyrosine and dehydrotyramine containing molecules; (b) simple dehydrodopa derivatives; (c) peptidyl dehydrotyrosine and dehydrodopa derivatives; (d) multiple dehydrodopa containing compounds; and (e) polycyclic condensed dehydrodopa derivatives. These molecules possess a wide range of biological activities that include (but are not limited to) antitumor activity, antibiotic activity, cytotoxicity, antioxidant activity, multidrug resistance reversal, cell division inhibition, immunomodulatory activity, HIV-integrase inhibition, anti-viral, and anti-feeding (or feeding deterrent) activity. This review summarizes the structure, distribution, possible biosynthetic origin, and biological activity, of the five categories of dehydrotyrosine and dehydrodopa containing compounds.
Keywords: marine alkaloids; bioactive peptides; dehydrotyrosine; dehydrodopa; dehydrotopa marine alkaloids; bioactive peptides; dehydrotyrosine; dehydrodopa; dehydrotopa
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |

MDPI and ACS Style

Sugumaran, M.; Robinson, W.E. Bioactive Dehydrotyrosyl and Dehydrodopyl Compounds of Marine Origin. Mar. Drugs 2010, 8, 2906-2935.

AMA Style

Sugumaran M, Robinson WE. Bioactive Dehydrotyrosyl and Dehydrodopyl Compounds of Marine Origin. Marine Drugs. 2010; 8(12):2906-2935.

Chicago/Turabian Style

Sugumaran, Manickam; Robinson, William E. 2010. "Bioactive Dehydrotyrosyl and Dehydrodopyl Compounds of Marine Origin." Mar. Drugs 8, no. 12: 2906-2935.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert