Next Article in Journal
Cytotoxic Terpene Quinones from Marine Sponges
Previous Article in Journal
Recent N-Atom Containing Compounds from Indo-Pacific Invertebrates
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2010, 8(11), 2837-2848; doi:10.3390/md8112848

Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum

1
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China
2
Analytical and Testing Center, Beijing Normal University, Beijing, 100875, China
3
Netherlands Centre for Biodiversity Naturalis, 2300 RA Leiden, The Netherlands
4
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Duesseldorf, Germany
*
Author to whom correspondence should be addressed.
Received: 1 October 2010 / Revised: 18 October 2010 / Accepted: 4 November 2010 / Published: 10 November 2010
View Full-Text   |   Download PDF [357 KB, uploaded 24 February 2015]   |  

Abstract

Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O–S (15) and a new “monomeric” cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae. View Full-Text
Keywords: soft coral; Lobophytum pauciflorum; lobophytones O–T; structure elucidation; NO inhibition; antibiotic activity   soft coral; Lobophytum pauciflorum; lobophytones O–T; structure elucidation; NO inhibition; antibiotic activity  
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Share & Cite This Article

MDPI and ACS Style

Yan, P.; Deng, Z.; Ofwegen, L.; Proksch, P.; Lin, W. Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum. Mar. Drugs 2010, 8, 2837-2848.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top