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Mar. Drugs 2010, 8(12), 2849-2870; doi:10.3390/md8122849
Review

Cytotoxic Terpene Quinones from Marine Sponges

Received: 7 October 2010 / Revised: 12 November 2010 / Accepted: 17 November 2010 / Published: 24 November 2010
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Abstract

The 1,4-benzoquinone moiety is a common structural feature in a large number of compounds that have received considerable attention owing to their broad spectrum of biological activities. The cytotoxic and antiproliferative properties of many natural sesquiterpene quinones and hydroquinones from sponges of the order Dictyoceratida, such as avarol, avarone, illimaquinone, nakijiquinone and bolinaquinone, offer promising opportunities for the development of new antitumor agents. The present review summarizes the structure and cytotoxicity of natural terpenequinones/hydroquinones and their bioactive analogues and derivatives.
Keywords: terpene quinone; terpene hydroquinone; avarone; avarol; cytotoxicity terpene quinone; terpene hydroquinone; avarone; avarol; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gordaliza, M. Cytotoxic Terpene Quinones from Marine Sponges. Mar. Drugs 2010, 8, 2849-2870.

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