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Cytotoxic Terpene Quinones from Marine Sponges
Department of Pharmaceutical Chemistry, Pharmacy Faculty, Salamanca University, Campus Miguel de Unamuno, 37007 Salamanca, Spain
Received: 7 October 2010; in revised form: 12 November 2010 / Accepted: 17 November 2010 / Published: 24 November 2010
Abstract: The 1,4-benzoquinone moiety is a common structural feature in a large number of compounds that have received considerable attention owing to their broad spectrum of biological activities. The cytotoxic and antiproliferative properties of many natural sesquiterpene quinones and hydroquinones from sponges of the order Dictyoceratida, such as avarol, avarone, illimaquinone, nakijiquinone and bolinaquinone, offer promising opportunities for the development of new antitumor agents. The present review summarizes the structure and cytotoxicity of natural terpenequinones/hydroquinones and their bioactive analogues and derivatives.
Keywords: terpene quinone; terpene hydroquinone; avarone; avarol; cytotoxicity
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MDPI and ACS Style
Gordaliza, M. Cytotoxic Terpene Quinones from Marine Sponges. Mar. Drugs 2010, 8, 2849-2870.
Gordaliza M. Cytotoxic Terpene Quinones from Marine Sponges. Marine Drugs. 2010; 8(12):2849-2870.
Gordaliza, Marina. 2010. "Cytotoxic Terpene Quinones from Marine Sponges." Mar. Drugs 8, no. 12: 2849-2870.