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Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China
Analytical and Testing Center, Beijing Normal University, Beijing, 100875, China
Netherlands Centre for Biodiversity Naturalis, 2300 RA Leiden, The Netherlands
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Duesseldorf, Germany
* Author to whom correspondence should be addressed.
Received: 1 October 2010; in revised form: 18 October 2010 / Accepted: 4 November 2010 / Published: 10 November 2010
Abstract: Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O–S (1–5) and a new “monomeric” cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.
Keywords: soft coral; Lobophytum pauciflorum; lobophytones O–T; structure elucidation; NO inhibition; antibiotic activity
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MDPI and ACS Style
Yan, P.; Deng, Z.; Ofwegen, L.; Proksch, P.; Lin, W. Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum. Mar. Drugs 2010, 8, 2837-2848.
Yan P, Deng Z, Ofwegen L, Proksch P, Lin W. Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum. Marine Drugs. 2010; 8(11):2837-2848.
Yan, Pengcheng; Deng, Zhiwei; Ofwegen, Leen van; Proksch, Peter; Lin, Wenhan. 2010. "Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum." Mar. Drugs 8, no. 11: 2837-2848.