Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum

doi:10.3390/md8112848

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Mar. Drugs 2010, 8(11), 2837-2848; doi:10.3390/md8112848

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Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum

Pengcheng Yan¹, Zhiwei Deng², Leen van Ofwegen³, Peter Proksch⁴ and Wenhan Lin^1,*

¹ State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China ² Analytical and Testing Center, Beijing Normal University, Beijing, 100875, China ³ Netherlands Centre for Biodiversity Naturalis, 2300 RA Leiden, The Netherlands ⁴ Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Duesseldorf, Germany

* Author to whom correspondence should be addressed.

Received: 1 October 2010; in revised form: 18 October 2010 / Accepted: 4 November 2010 / Published: 10 November 2010

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Abstract: Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O–S (1–5) and a new “monomeric” cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.

Keywords: soft coral; Lobophytum pauciflorum; lobophytones O–T; structure elucidation; NO inhibition; antibiotic activity

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Cite This Article

MDPI and ACS Style

Yan, P.; Deng, Z.; Ofwegen, L.; Proksch, P.; Lin, W. Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum. Mar. Drugs 2010, 8, 2837-2848.

AMA Style

Yan P., Deng Z., Ofwegen L., Proksch P., Lin W. Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum. Marine Drugs. 2010; 8(11):2837-2848.

Chicago/Turabian Style

Yan, Pengcheng; Deng, Zhiwei; Ofwegen, Leen van; Proksch, Peter; Lin, Wenhan. 2010. "Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum." Mar. Drugs 8, no. 11: 2837-2848.

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