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Mar. Drugs 2010, 8(11), 2837-2848; doi:10.3390/md8112848
Article

Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum

1
,
2
,
3
,
4
 and
1,*
1 State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China 2 Analytical and Testing Center, Beijing Normal University, Beijing, 100875, China 3 Netherlands Centre for Biodiversity Naturalis, 2300 RA Leiden, The Netherlands 4 Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Duesseldorf, Germany
* Author to whom correspondence should be addressed.
Received: 1 October 2010 / Revised: 18 October 2010 / Accepted: 4 November 2010 / Published: 10 November 2010
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Abstract

Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O–S (15) and a new “monomeric” cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria Saureus and S. pneumoniae.
Keywords: soft coral; Lobophytum pauciflorum; lobophytones O–T; structure elucidation; NO inhibition; antibiotic activity   soft coral; Lobophytum pauciflorum; lobophytones O–T; structure elucidation; NO inhibition; antibiotic activity  
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yan, P.; Deng, Z.; Ofwegen, L.; Proksch, P.; Lin, W. Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum. Mar. Drugs 2010, 8, 2837-2848.

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