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Mar. Drugs 2010, 8(11), 2795-2809; doi:10.3390/md8112795
Article

Antimutagenicity and Antiproliferative Studies of Lipidic Extracts from White Shrimp (Litopenaeus vannamei)

1
, 1
, 2,†
, 1
, 2
, 3
, 1
, 1
, 2
 and 1,†,*
1 Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Apartado Postal 1658, Hermosillo, Sonora, Mexico 2 Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Apartado Postal 1658, Hermosillo, Sonora, Mexico 3 Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Apartado Postal 1658, Hermosillo, Sonora, Mexico These authors contributed equally to this research work.
* Author to whom correspondence should be addressed.
Received: 26 September 2010 / Revised: 14 October 2010 / Accepted: 2 November 2010 / Published: 8 November 2010
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Abstract

An organic extract from fresh shrimp (Litopenaeus vannamei) was studied for antimutagenic and antiproliferative properties using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. Shrimp extract was sequentially fractionated by thin layer chromatography (TLC) and each fraction was tested for antimutagenic and antiproliferative activities. Crude organic extracts obtained from shrimp reduced the number of revertants caused by aflatoxina B1, showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. These results suggested that the lipid fraction of the tested species contained compounds with chemoprotective properties that reduce the mutagenicity of AFB1 and proliferation of a cancer cell line.
Keywords: antimutagenicity; antiproliferation; cultured shrimp antimutagenicity; antiproliferation; cultured shrimp
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wilson-Sanchez, G.; Moreno-Félix, C.; Velazquez, C.; Plascencia-Jatomea, M.; Acosta, A.; Machi-Lara, L.; Aldana-Madrid, M.-L.; Ezquerra-Brauer, J.-M.; Robles-Zepeda, R.; Burgos-Hernandez, A. Antimutagenicity and Antiproliferative Studies of Lipidic Extracts from White Shrimp (Litopenaeus vannamei). Mar. Drugs 2010, 8, 2795-2809.

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