Mar. Drugs 2010, 8(11), 2795-2809; doi:10.3390/md8112795
Article

Antimutagenicity and Antiproliferative Studies of Lipidic Extracts from White Shrimp (Litopenaeus vannamei)

Griselda Wilson-Sanchez 1 email, Carolina Moreno-Félix 1 email, Carlos Velazquez 2,† email, Maribel Plascencia-Jatomea 1 email, Anita Acosta 2 email, Lorena Machi-Lara 3 email, María-Lourdes Aldana-Madrid 1 email, Josafat-Marina Ezquerra-Brauer 1 email, Ramón Robles-Zepeda 2 email and Armando Burgos-Hernandez 1,†,* email
1 Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Apartado Postal 1658, Hermosillo, Sonora, Mexico 2 Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Apartado Postal 1658, Hermosillo, Sonora, Mexico 3 Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Apartado Postal 1658, Hermosillo, Sonora, Mexico † These authors contributed equally to this research work.
* Author to whom correspondence should be addressed.
Received: 26 September 2010; in revised form: 14 October 2010 / Accepted: 2 November 2010 / Published: 8 November 2010
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Abstract: An organic extract from fresh shrimp (Litopenaeus vannamei) was studied for antimutagenic and antiproliferative properties using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. Shrimp extract was sequentially fractionated by thin layer chromatography (TLC) and each fraction was tested for antimutagenic and antiproliferative activities. Crude organic extracts obtained from shrimp reduced the number of revertants caused by aflatoxina B1, showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. These results suggested that the lipid fraction of the tested species contained compounds with chemoprotective properties that reduce the mutagenicity of AFB1 and proliferation of a cancer cell line.
Keywords: antimutagenicity; antiproliferation; cultured shrimp

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MDPI and ACS Style

Wilson-Sanchez, G.; Moreno-Félix, C.; Velazquez, C.; Plascencia-Jatomea, M.; Acosta, A.; Machi-Lara, L.; Aldana-Madrid, M.-L.; Ezquerra-Brauer, J.-M.; Robles-Zepeda, R.; Burgos-Hernandez, A. Antimutagenicity and Antiproliferative Studies of Lipidic Extracts from White Shrimp (Litopenaeus vannamei). Mar. Drugs 2010, 8, 2795-2809.

AMA Style

Wilson-Sanchez G, Moreno-Félix C, Velazquez C, Plascencia-Jatomea M, Acosta A, Machi-Lara L, Aldana-Madrid M-L, Ezquerra-Brauer J-M, Robles-Zepeda R, Burgos-Hernandez A. Antimutagenicity and Antiproliferative Studies of Lipidic Extracts from White Shrimp (Litopenaeus vannamei). Marine Drugs. 2010; 8(11):2795-2809.

Chicago/Turabian Style

Wilson-Sanchez, Griselda; Moreno-Félix, Carolina; Velazquez, Carlos; Plascencia-Jatomea, Maribel; Acosta, Anita; Machi-Lara, Lorena; Aldana-Madrid, María-Lourdes; Ezquerra-Brauer, Josafat-Marina; Robles-Zepeda, Ramón; Burgos-Hernandez, Armando. 2010. "Antimutagenicity and Antiproliferative Studies of Lipidic Extracts from White Shrimp (Litopenaeus vannamei)." Mar. Drugs 8, no. 11: 2795-2809.

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