Mar. Drugs 2010, 8(11), 2744-2754; doi:10.3390/md8112744
Article

Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum

Ke Yu 1,2 , Biao Ren 1,2 , Junli Wei 3 , Caixia Chen 1 , Jinsheng Sun 3 , Fuhang Song 1 , Huanqin Dai 1  and Lixin Zhang 1,* email
1 Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China 2 Graduate University of Chinese Academy of Sciences, Beijing 100190, China 3 Tianjin Normal University, Tianjin 300387, China
* Author to whom correspondence should be addressed.
Received: 1 October 2010; in revised form: 22 October 2010 / Accepted: 26 October 2010 / Published: 1 November 2010
(This article belongs to the Special Issue Marine Natural Products - Advances in Separation, Characterisation and Chemical Profiling Methodologies)
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Abstract: The new secondary metabolites verrucosidinol (1) and its derivative verrucosidinol acetate (2), together with a potent neurotoxin verrucosidin (3), a congener norverrucosidin (4) and a mixture of two known phytotoxic metabolites terrestric acids (5 and 6), were isolated from the marine derived fungus Penicillium aurantiogriseum. Verrucosidinol has a ring-opened ethylene oxide moiety in the polyene α-pyrone skeleton, and verrucosidinol acetate is its acetate derivative. The chemical structures were determined by comparing with literature data and a combination of spectroscopic techniques, including high resolution mass spectrum and two-dimentional nuclear magnetic resonance spectroscopic analysis.
Keywords: marine fungus; Penicillium aurantiogriseum; verrucosidin

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Cite This Article

MDPI and ACS Style

Yu, K.; Ren, B.; Wei, J.; Chen, C.; Sun, J.; Song, F.; Dai, H.; Zhang, L. Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum. Mar. Drugs 2010, 8, 2744-2754.

AMA Style

Yu K, Ren B, Wei J, Chen C, Sun J, Song F, Dai H, Zhang L. Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum. Marine Drugs. 2010; 8(11):2744-2754.

Chicago/Turabian Style

Yu, Ke; Ren, Biao; Wei, Junli; Chen, Caixia; Sun, Jinsheng; Song, Fuhang; Dai, Huanqin; Zhang, Lixin. 2010. "Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum." Mar. Drugs 8, no. 11: 2744-2754.

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