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Mar. Drugs 2010, 8(11), 2744-2754; doi:10.3390/md8112744

Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum

1
Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China
2
Graduate University of Chinese Academy of Sciences, Beijing 100190, China
3
Tianjin Normal University, Tianjin 300387, China
*
Author to whom correspondence should be addressed.
Received: 1 October 2010 / Revised: 22 October 2010 / Accepted: 26 October 2010 / Published: 1 November 2010
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Abstract

The new secondary metabolites verrucosidinol (1) and its derivative verrucosidinol acetate (2), together with a potent neurotoxin verrucosidin (3), a congener norverrucosidin (4) and a mixture of two known phytotoxic metabolites terrestric acids (5 and 6), were isolated from the marine derived fungus Penicillium aurantiogriseum. Verrucosidinol has a ring-opened ethylene oxide moiety in the polyene α-pyrone skeleton, and verrucosidinol acetate is its acetate derivative. The chemical structures were determined by comparing with literature data and a combination of spectroscopic techniques, including high resolution mass spectrum and two-dimentional nuclear magnetic resonance spectroscopic analysis.
Keywords: marine fungus; Penicillium aurantiogriseum; verrucosidin marine fungus; Penicillium aurantiogriseum; verrucosidin
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MDPI and ACS Style

Yu, K.; Ren, B.; Wei, J.; Chen, C.; Sun, J.; Song, F.; Dai, H.; Zhang, L. Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum. Mar. Drugs 2010, 8, 2744-2754.

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