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• Vagias, C
• Roussis, V
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• Vagias, C
• Roussis, V

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Mar. Drugs 2009, 7(2), 184-195; doi:10.3390/md7020184

Article

Sphaeroane and Neodolabellane Diterpenes from the Red Alga Sphaerococcus coronopifolius

Vangelis Smyrniotopoulos, Constantinos Vagias and Vassilios Roussis*

Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece

* Author to whom correspondence should be addressed.

Received: 17 April 2009; in revised form: 4 May 2009 / Accepted: 18 May 2009 / Published: 19 May 2009

Download PDF Full-Text [318 KB, uploaded 19 May 2009 16:00 CEST]

Abstract: Investigation of minor metabolites in the extracts of the red alga Sphaerococcus coronopifolius collected from the rocky coasts of Corfu Island in the Ionian Sea yielded two new diterpene alcohols, sphaerollanes I,and II (1, 2) featuring neodolabellane skeletons, and the new sphaeroane diterpene alcohol 16-hydroxy-9S*-acetoxy-8-epi-isosphaerodiene-2 (3), along with two previously reported metabolites 4, 5. The structures of the new natural products, as well as their relative stereochemistry, were elucidated on the basis of extensive spectral analysis, including 2D-NMR experiments.

Keywords: Sphaerococcus coronopifolius; diterpenes; neodolabellanes; sphaeroanes

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