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Molecular Structure of Endotoxins from Gram-negative Marine Bacteria: An Update
AbstractMarine bacteria are microrganisms that have adapted, through millions of years, to survival in environments often characterized by one or more extreme physical or chemical parameters, namely pressure, temperature and salinity. The main interest in the research on marine bacteria is due to their ability to produce several biologically active molecules, such as antibiotics, toxins and antitoxins, antitumor and antimicrobial agents. Nonetheless, lipopolysaccharides (LPSs), or their portions, from Gram-negative marine bacteria, have often shown low virulence, and represent potential candidates in the development of drugs to prevent septic shock. Besides, the molecular architecture of such molecules is related to the possibility of thriving in marine habitats, shielding the cell from the disrupting action of natural stress factors. Over the last few years, the depiction of a variety of structures of lipids A, core oligosaccharides and O-specific polysaccharides from LPSs of marine microrganisms has been given. In particular, here we will examine the most recently encountered structures for bacteria belonging to the genera Shewanella, Pseudoalteromonas and Alteromonas, of the γ-Proteobacteria phylum, and to the genera Flavobacterium, Cellulophaga, Arenibacter and Chryseobacterium, of the Cytophaga- Flavobacterium-Bacteroides phylum. Particular attention will be paid to the chemical features expressed by these structures (characteristic monosaccharides, non-glycidic appendages, phosphate groups), to the typifying traits of LPSs from marine bacteria and to the possible correlation existing between such features and the adaptation, over years, of bacteria to marine environments.
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Leone, S.; Silipo, A.; Nazarenko, E.L.; Lanzetta, R.; Parrilli, M.; Molinaro, A. Molecular Structure of Endotoxins from Gram-negative Marine Bacteria: An Update. Mar. Drugs 2007, 5, 85-112.View more citation formats
Leone S, Silipo A, Nazarenko EL, Lanzetta R, Parrilli M, Molinaro A. Molecular Structure of Endotoxins from Gram-negative Marine Bacteria: An Update. Marine Drugs. 2007; 5(3):85-112.Chicago/Turabian Style
Leone, Serena; Silipo, Alba; Nazarenko, Evgeny L.; Lanzetta, Rosa; Parrilli, Michelangelo; Molinaro, Antonio. 2007. "Molecular Structure of Endotoxins from Gram-negative Marine Bacteria: An Update." Mar. Drugs 5, no. 3: 85-112.