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Mar. Drugs 2007, 5(1), 1-5; doi:10.3390/md501001
Article

Effects of Melophlins on Colony Formation of Chinese Hamster V79 Cells and IL-8 Production in PMA-stimulated HL-60 Cells

1,* , 2
,
2
,
1
,
3
 and
3
1 Kyoritsu University of Pharmacy, Shibakoen, Minato-ku, Tokyo 105-8512, Japan 2 Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan 3 Tohoku Pharmaceutical University, Komatsushima, Aoba-ku, Sendai 981-8558, Japan
* Author to whom correspondence should be addressed.
Received: 30 November 2006 / Accepted: 18 January 2007 / Published: 18 January 2007
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Abstract

We have recently isolated four new melophlins P (1), Q (2), R (3), and S (4) together with seven known melophlins A (5), D (6), E (7), G (8), H (9), I (10), and O (11) from two marine sponges of the genus Melophlus collected in Palau. In this study, the influence of these compounds on the colony formation of Chinese hamster V79 cells and the production of IL-8 in PMA-stimulated HL-60 cells were examined. These 11 compounds did not show any effect on IL-8 production. The EC50 values of compounds 2, 3, 4, 5, 7, 9, 10, and 11 against V79 cells were 44.0, 13.3, 16.7, 27.2, 19.8, 8.5, 23.1, and 9.6 μM, respectively. The linear-chain-type compounds (1, 6, and 8) were not active against V79 cells at 50 μM. Although the growth inhibitory activity of these melophlins was not remarkable, some structure-activity relationships of these compounds against V79 and murine leukemia L1210 cells were observed.
Keywords: Melophlin; marine sponge; Melophlus sp.; V79 cell; cell proliferation. Melophlin; marine sponge; Melophlus sp.; V79 cell; cell proliferation.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Oda, T.; Fujita, A.; Xu, J.; Mochizuki, M.; Ukai, K.; Namikoshi, M. Effects of Melophlins on Colony Formation of Chinese Hamster V79 Cells and IL-8 Production in PMA-stimulated HL-60 Cells. Mar. Drugs 2007, 5, 1-5.

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