Mar. Drugs 2005, 3(4), 119-125; doi:10.3390/md304119
Article

Effects of Polybrominated Diphenol Ethers from a Marine Sponge Phyllospongia dendyi on IL-8 Production in a PMAstimulated Promyelocytic Leukemia Cell Line

1,* email, 2 and 2
Received: 28 August 2005; Accepted: 3 November 2005 / Published: 3 November 2005
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The effects of five polybrominated diphenol ethers from a Marine Sponge, Phyllospongia dendyi, on the relative plating efficiencies in V79 cells and the cell proliferation and IL-8 production in PMA-stimulated HL-60 cells were examined. Three compounds, possessing two phenol units, were reported to inhibit the assembly of microtubule proteins and showed the inhibition of colony formation of V79 cells and increase in IL-8 production. Interestingly, a monomethoxy compound exhibited the stronger activity than the three active compounds in both bioassays. This compound did not inhibit the assembly of microtubule proteins. A dimethoxy compound was not active in either bioassays. In these experimental conditions, the biological activities were not high, but in future, these compounds will be expected to be made stronger by structural modifications.
Keywords: polybrominated diphenol ether; relative plating efficiency; V79 cell; IL-8; HL-60 cell
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MDPI and ACS Style

Oda, T.; Liu, H.; Namikoshi, M. Effects of Polybrominated Diphenol Ethers from a Marine Sponge Phyllospongia dendyi on IL-8 Production in a PMAstimulated Promyelocytic Leukemia Cell Line. Mar. Drugs 2005, 3, 119-125.

AMA Style

Oda T, Liu H, Namikoshi M. Effects of Polybrominated Diphenol Ethers from a Marine Sponge Phyllospongia dendyi on IL-8 Production in a PMAstimulated Promyelocytic Leukemia Cell Line. Marine Drugs. 2005; 3(4):119-125.

Chicago/Turabian Style

Oda, Taiko; Liu, Hongwei; Namikoshi, Michio. 2005. "Effects of Polybrominated Diphenol Ethers from a Marine Sponge Phyllospongia dendyi on IL-8 Production in a PMAstimulated Promyelocytic Leukemia Cell Line." Mar. Drugs 3, no. 4: 119-125.

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