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Table of Contents

Mar. Drugs, Volume 3, Issue 4 (December 2005), Pages 113-126

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	p. 113-118 Takaaki Kubota, Ayako Takahashi, Masashi Tsuda and Jun\'ichi Kobayashi Article: Luteophanol D, New Polyhydroxyl Metabolite from Marine Dinoflagellate Amphidinium sp. Mar. Drugs 2005, 3(4), 113-118; doi:10.3390/md304113 Received: 20 October 2005 / Accepted: 2 November 2005 / Published: 2 November 2005 Show/Hide Abstract | Download PDF Full-text (50 KB) Abstract: Luteophanol D (1), a new polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from Okinawan marine acoel flatworm Pseudaphanostoma luteocoloris. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Luteophanol D (1) possesses two tetrahydropyran rings and twenty-three hydroxyl groups on C63-linear aliphatic chain with one exo-methylene and two methyl branches.
	p. 119-125 Taiko Oda, Hongwei Liu and Michio Namikoshi Article: Effects of Polybrominated Diphenol Ethers from a Marine Sponge Phyllospongia dendyi on IL-8 Production in a PMAstimulated Promyelocytic Leukemia Cell Line Mar. Drugs 2005, 3(4), 119-125; doi:10.3390/md304119 Received: 28 August 2005 / Accepted: 3 November 2005 / Published: 3 November 2005 Show/Hide Abstract | Download PDF Full-text (70 KB) Abstract: The effects of five polybrominated diphenol ethers from a Marine Sponge, Phyllospongia dendyi, on the relative plating efficiencies in V79 cells and the cell proliferation and IL-8 production in PMA-stimulated HL-60 cells were examined. Three compounds, possessing two phenol units, were reported to inhibit the assembly of microtubule proteins and showed the inhibition of colony formation of V79 cells and increase in IL-8 production. Interestingly, a monomethoxy compound exhibited the stronger activity than the three active compounds in both bioassays. This compound did not inhibit the assembly of microtubule proteins. A dimethoxy compound was not active in either bioassays. In these experimental conditions, the biological activities were not high, but in future, these compounds will be expected to be made stronger by structural modifications.
	p. 126 Peter Proksch Editorial: Farewell Address of Marine Drugs Executive Editor-in-Chief Mar. Drugs 2005, 3(4), 126; doi:10.3390/md304126 Received: 22 December 2005 / Published: 22 December 2005 Show/Hide Abstract | Download PDF Full-text (13 KB) Abstract: n/a
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