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Table of Contents

Mar. Drugs, Volume 2, Issue 2 (June 2004), Pages 55-82

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	p. 55-62 Yoichi Nakao, Takeru Shiroiwa, Shuhei Murayama, Shigeki Matsunaga, Yasuyuki Goto, Yoshitsugu Matsumoto and Nobuhiro Fusetani Article: Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp. Mar. Drugs 2004, 2(2), 55-62; doi:10.3390/md202055 Received: 15 October 2003 / Accepted: 15 March 2004 / Published: 25 May 2004 Show/Hide Abstract | Download PDF Full-text (160 KB) Abstract: The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 μg/mL.
	p. 63-72 Kanami Mori, Takashi Ooi, Masanori Hiraoka, Naohiro Oka, Hideyuki Hamada, Mitsumasa Tamura and Takenori Kusumi Article: Fucoxanthin and Its Metabolites in Edible Brown Algae Cultivated in Deep Seawater Mar. Drugs 2004, 2(2), 63-72; doi:10.3390/md202063 Received: 21 April 2004 / Accepted: 8 May 2004 / Published: 25 May 2004 Show/Hide Abstract | Download PDF Full-text (173 KB) Abstract: Three metabolites of fucoxanthin were isolated from a brown alga, Scytosiphon lomentaria, and the structure of a new compound was determined by NMR. The content of fucoxanthin, a biologically active carotenoid, in four edible brown algae, cultivated in deep seawater, was studied.
	p. 73-82 Anake Kijjoa and Pichan Sawangwong Review: Drugs and Cosmetics from the Sea Mar. Drugs 2004, 2(2), 73-82; doi:10.3390/md202073 Received: 27 April 2004 / Accepted: 13 May 2004 / Published: 25 May 2004 Show/Hide Abstract | Download PDF Full-text (86 KB) Abstract: The marine environment is a rich source of both biological and chemical diversity. This diversity has been the source of unique chemical compounds with the potential for industrial development as pharmaceuticals, cosmetics, nutritional supplements, molecular probes, fine chemicals and agrochemicals. In recent years, a significant number of novel metabolites with potent pharmacological properties has been discovered from the marine organisms. Although there are only a few marine-derived products currently on the market, several robust new compounds derived from marine natural products are now in the clinical pipeline, with more clinical development. While the marine world offers an extremely rich resource for novel compounds, it also represents a great challenge that requires inputs from various scientific areas to bring the marine chemical diversity up to its therapeutic potential.
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