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Mar. Drugs 2004, 2(2), 55-62; doi:10.3390/md202055
Article

Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.

1, 1, 1, 1, 2, 2 and 1,*
1 Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan 2 Department of Molecular Immunology, Graduate School of Agricultural and life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
* Author to whom correspondence should be addressed.
Received: 15 October 2003 / Accepted: 15 March 2004 / Published: 25 May 2004
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Abstract

The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 μg/mL.
Keywords: leishmaniasis; marine sponge; renieramycin A leishmaniasis; marine sponge; renieramycin A
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nakao, Y.; Shiroiwa, T.; Murayama, S.; Matsunaga, S.; Goto, Y.; Matsumoto, Y.; Fusetani, N. Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.. Mar. Drugs 2004, 2, 55-62.

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