Mar. Drugs 2004, 2(2), 55-62; doi:10.3390/md202055
Article

Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.

1 Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan 2 Department of Molecular Immunology, Graduate School of Agricultural and life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
* Author to whom correspondence should be addressed.
Received: 15 October 2003; Accepted: 15 March 2004 / Published: 25 May 2004
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Abstract: The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 μg/mL.
Keywords: leishmaniasis; marine sponge; renieramycin A

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MDPI and ACS Style

Nakao, Y.; Shiroiwa, T.; Murayama, S.; Matsunaga, S.; Goto, Y.; Matsumoto, Y.; Fusetani, N. Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.. Mar. Drugs 2004, 2, 55-62.

AMA Style

Nakao Y, Shiroiwa T, Murayama S, Matsunaga S, Goto Y, Matsumoto Y, Fusetani N. Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.. Marine Drugs. 2004; 2(2):55-62.

Chicago/Turabian Style

Nakao, Yoichi; Shiroiwa, Takeru; Murayama, Shuhei; Matsunaga, Shigeki; Goto, Yasuyuki; Matsumoto, Yoshitsugu; Fusetani, Nobuhiro. 2004. "Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.." Mar. Drugs 2, no. 2: 55-62.

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